Jun Purumea, Zhao HuiYan, Kwon Ojin, Jang Jung-Hee
KM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of Korea.
University of Science & Technology, Campus of Korea Institute of Oriental Medicine, Korean Convergence Medicine Major, 217 Gajeong-ro Yuseong-gu, Daejeon, Republic of Korea.
Evid Based Complement Alternat Med. 2022 Apr 30;2022:4777849. doi: 10.1155/2022/4777849. eCollection 2022.
Parkinson's disease (PD), the second most common progressive neurodegenerative disease, is characterized by various clinical symptoms and reduced quality of life. The standard dopaminergic therapy for PD has limitations such as drug wear-off, drug-related side effects, and drug-resistant PD symptoms. Traditional oriental medicine, which is a personalized approach based on pattern identification (PI), has been reported to relieve symptoms, halt disease progression, and improve the quality of life in patients with PD. This comprehensive systematic review will be conducted to gather clinical studies related to complementary traditional herbal therapies based on PI for idiopathic PD and assess its effectiveness. Clinical studies, including randomized controlled trials in English, Korean, and Chinese databases related to the efficacy of herbal medicine based on PI for PD will be searched in computer retrieval. In addition, the subdivided PI for each clinical manifestation of PD will be investigated. Two researchers will independently screen and select studies, extract data, and assess bias risk. The risk of bias will be evaluated using the Cochrane risk-of-bias assessment tool. After screening the studies, a meta-analysis will be performed. The primary outcome will be the unified Parkinson's disease rating scale to measure clinical symptom reduction. Secondary outcomes will consist of other validated scales to evaluate the improvement of PD, including improvement of clinical symptoms and quality of life. The quality of evidence will be evaluated through the Grading of Recommendations, Assessment, Development, and Evaluation pro. Complementary traditional medicine is a personalized medicine that classifies individual states based on PI. We expect that the results of this review will provide evidence for the efficacy of traditional herbal medicine based on PI for the treatment of PD. This protocol has been registered in the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) 2021 (registration number INPLASY2021100020).
帕金森病（PD）是第二常见的进行性神经退行性疾病，其特征为各种临床症状和生活质量下降。PD的标准多巴胺能疗法存在局限性，如药物疗效减退、药物相关副作用以及耐药性PD症状。据报道，传统东方医学是一种基于辨证论治（PI）的个性化方法，可缓解症状、阻止疾病进展并改善PD患者的生活质量。本综述将全面系统地收集与基于PI的特发性PD补充传统草药疗法相关的临床研究，并评估其有效性。将通过计算机检索在英文、韩文和中文数据库中搜索与基于PI的草药治疗PD疗效相关的临床研究，包括随机对照试验。此外，还将研究PD各临床表现的细分辨证。两名研究人员将独立筛选和选择研究、提取数据并评估偏倚风险。将使用Cochrane偏倚风险评估工具评估偏倚风险。筛选研究后，将进行荟萃分析。主要结局将是统一帕金森病评定量表，以衡量临床症状的减轻。次要结局将包括其他经过验证的量表，以评估PD的改善情况，包括临床症状和生活质量的改善。证据质量将通过推荐分级、评估、制定和评价程序进行评估。补充传统医学是一种基于PI对个体状态进行分类的个性化医学。我们期望本综述的结果将为基于PI的传统草药治疗PD的疗效提供证据。本方案已在国际注册系统评价和荟萃分析方案平台（INPLASY）2021年注册（注册号INPLASY2021100020）。
