D-二聚体/肌酐比值：ST 段抬高型心肌梗死患者与 Gensini 评分相关的新型生物标志物。
D-dimer to Creatinine Ratio: A Novel Biomarker Associated with Gensini Score in ST-Segment Elevation Myocardial Infarction Patients.
机构信息
Department of Gastroenterology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, China.
Department of Gastroenterology, 576469Shanghai Songjiang District Central Hospital, Shanghai, China.
出版信息
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221099938. doi: 10.1177/10760296221099938.
OBJECTIVE
We propose for the first time that D-dimer to creatinine ratio (DCR) may serve as a new clinical biomarker and explore its association with ST-segment elevation myocardial infarction (STEMI).
METHODS
347 STEMI patients with complete D-dimer and creatinine were included in the analysis. According to the median of DCR value, patients were divided into the lower DCR group (DCR < 1.402, n = 173) and the higher DCR group (DCR ≥ 1.402, n = 174), and the differences between the two groups were compared. In addition, patients were divided into four groups according to the quartiles of Gensini score: Group 1(Gensini score ≤ 34, n = 88); Group 2(34 < Gensini score ≤ 65, n = 88); Group 3(65 < Gensini score ≤100, n = 87); Group 4(Gensini score ＞100, n = 84). Multivariate linear and multivariate logistic regression analyzes were performed to determine independent predictors of the Gensini score.
RESULTS
High DCR group had higher Gensini score compared with the low DCR group ( < .05). DCR was positively correlated with Gensini score (r = 0.493, < .001). Multiple linear regression analysis showed that Previous MI (r = 11.312, = .035) and DCR (r = 5.129, < .001) were independent risk factors associated with the Gensini score. Multivariate logistic regression analysis showed that, compared to Group 1, DCR was an independent risk factor in Group 2, Group 3, Group 4 ( < .001).
CONCLUSIONS
As a new and useful clinical biomarker, DCR was positively correlated with coronary Gensini score in STEMI patients.
目的
我们首次提出 D-二聚体与肌酐比值（DCR）可能作为一种新的临床生物标志物，并探讨其与 ST 段抬高型心肌梗死（STEMI）的关系。
方法
共纳入 347 例 D-二聚体和肌酐完整的 STEMI 患者进行分析。根据 DCR 值中位数将患者分为低 DCR 组（DCR＜1.402，n＝173）和高 DCR 组（DCR≥1.402，n＝174），比较两组间差异。另外，根据 Gensini 评分四分位数将患者分为四组：第 1 组（Gensini 评分≤34，n＝88）；第 2 组（34＜Gensini 评分≤65，n＝88）；第 3 组（65＜Gensini 评分≤100，n＝87）；第 4 组（Gensini 评分＞100，n＝84）。采用多元线性和多元逻辑回归分析确定 Gensini 评分的独立预测因子。
结果
高 DCR 组的 Gensini 评分高于低 DCR 组（ < .05）。DCR 与 Gensini 评分呈正相关（r＝0.493， < .001）。多元线性回归分析显示，既往心肌梗死（r＝11.312， = .035）和 DCR（r＝5.129， < .001）是与 Gensini 评分相关的独立危险因素。多元逻辑回归分析显示，与第 1 组相比，DCR 是第 2、3、4 组的独立危险因素（ < .001）。
结论
作为一种新的有用的临床生物标志物，DCR 与 STEMI 患者的冠状动脉 Gensini 评分呈正相关。
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