Department of Paediatrics and Adolescent Medicine, Nordsjaellands Hospital in Hilleroed, Hilleroed, Denmark.
The Danish Clinical Quality Program - National Clinical Registries (RKKP), Aarhus, Denmark.
Acta Paediatr. 2022 Sep;111(9):1695-1700. doi: 10.1111/apa.16401. Epub 2022 May 17.
Our aim was to investigate the rates of preterm births, live births and stillbirths in Denmark during the first year of the COVID-19 pandemic.
This was a national, cross-sectional registry-based study that used the Danish Newborn Quality database, which covers all births in Denmark. The proportions of preterm births were compared between the COVID-19 pandemic period of 1 March 2020 to 28 February 2021 and the preceding 4-year pre-pandemic period.
We studied 60 323 and 244 481 newborn infants from the pandemic and pre-pandemic periods, respectively. The proportion of preterm live births and stillbirths declined slightly, from 6.29% during the pre-pandemic period to 6.02% during the pandemic period. This corresponded to a relative risk (RR) of 0.96, with a 95% confidence interval (CI) of 0.93-0.99 during the pandemic. The RRs for extremely preterm, very preterm and moderately preterm infants were 0.88 (95% CI 0.76-1.02), 0.91 (95% CI 0.82-1.02) and 0.97 (95% CI 0.93-1.01), respectively.
This comparative study showed a small reduction in just over 4%, from 6.29 to 6.02% in the proportion of all preterm births during the pandemic period, compared with the previous four pandemic-free years. There were no differences between subcategories of preterm births.
本研究旨在调查丹麦在 COVID-19 大流行第一年的早产、活产和死产发生率。
这是一项全国性的、基于登记的横断面研究,使用丹麦新生儿质量数据库,该数据库涵盖了丹麦所有的分娩。比较了 COVID-19 大流行期间(2020 年 3 月 1 日至 2021 年 2 月 28 日)和之前的 4 年大流行前期间早产的比例。
我们研究了大流行期间的 60323 名和大流行前期间的 244481 名新生儿。早产活产和死产的比例略有下降,从大流行前时期的 6.29%下降到大流行时期的 6.02%。这对应于相对风险(RR)为 0.96,95%置信区间(CI)为 0.93-0.99。极早产、非常早产和中度早产婴儿的 RR 分别为 0.88(95%CI 0.76-1.02)、0.91(95%CI 0.82-1.02)和 0.97(95%CI 0.93-1.01)。
与前四年无大流行时期相比,这项比较研究显示,大流行期间所有早产的比例略有下降,从 6.29%降至 6.02%,降幅略高于 4%。早产各亚类之间无差异。