Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, National Clinical Research Center for Geriatrics, West China Hospital, College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610041, China.
Huaxi MR Research Center, Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chem Soc Rev. 2022 May 23;51(10):4175-4198. doi: 10.1039/d1cs01165k.
Polyphenolic materials are a class of fascinating and versatile bioinspired materials for biointerfacial engineering. In particular, due to the presence of active chemical groups, a series of unique physicochemical properties become accessible and tunable of the as-prepared polyphenolic platforms, which could delicately regulate the cell activities cell-material contact-dependent interactions. More interestingly, polyphenols could also affect the cell behaviors cell-material contact-independent manner, which arise due to their intrinsically functional characteristics (, antioxidant and photothermal behaviors). As such, a comprehensive understanding on the relationship between material properties and desired biomedical applications, as well as the underlying mechanism at the cellular and molecular level would provide material design principles and accelerate the lab-to-clinic translation of polyphenolic platforms. In this review, we firstly give a brief overview of cell hallmarks governed by surrounding cues, followed by the introduction of polyphenolic material engineering strategies. Subsequently, a detailed discussion on cell-polyphenols contact-dependent interfacial interaction and contact-independent interaction was also carefully provided. Lastly, their biomedical applications were elaborated. We believe that this review could provide guidances for the rational material design of multifunctional polyphenols and extend their application window.
多酚材料是一类引人入胜且用途广泛的仿生材料，可用于生物界面工程。特别是由于存在活性化学基团，一系列独特的物理化学性质变得易于获得和可调谐，这使得所制备的多酚平台能够精细调节细胞活性和细胞-材料接触依赖性相互作用。更有趣的是，多酚还可以以细胞-材料非接触依赖的方式影响细胞行为，这是由于其内在的功能特性（抗氧化和光热行为）所致。因此，全面了解材料特性与所需生物医学应用之间的关系，以及在细胞和分子水平上的潜在机制，将为材料设计原则提供指导，并加速多酚平台从实验室向临床的转化。在这篇综述中，我们首先简要概述了受周围线索控制的细胞特征，然后介绍了多酚材料工程策略。随后，还仔细讨论了细胞-多酚接触依赖性界面相互作用和非接触依赖性相互作用。最后，阐述了它们的生物医学应用。我们相信，这篇综述可为多功能多酚的合理材料设计提供指导，并扩展其应用范围。
