National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300131, P.R. China.
Key Laboratory of Hebei Province for Molecular Biophysics, Institute of Biophysics, Hebei University of Technology, Tianjin 300401, P.R. China.
ACS Appl Bio Mater. 2022 Jun 20;5(6):2536-2542. doi: 10.1021/acsabm.2c00288. Epub 2022 May 10.
Mild-temperature photothermal therapy (PTT) is being extensively explored because it causes less injury to normal cells. However, the effect of mild-temperature PTT is decreased because of heat shock protein (HSP) overexpression. To solve this problem, we designed functional conjugated polymer nanoparticles (CPNs-G) that enhance the mild-temperature photothermal effect. Upon near-infrared (NIR) light irradiation, CPNs-G generate local heat to realize the photothermal effect. Meanwhile, the increased temperature enhances the catalytic activity of GOx, thus impeding the generation of adenosine triphosphate (ATP) and inhibiting HSP expression. Therefore, this work provides a strategy for overcoming thermoresistance through an enzyme-mediated starvation effect regulated by NIR light.
温和温度光热疗法（PTT）正被广泛研究，因为它对正常细胞的损伤较小。然而，由于热休克蛋白（HSP）过表达，温和温度 PTT 的效果降低。为了解决这个问题，我们设计了功能化共轭聚合物纳米粒子（CPNs-G），以增强温和温度光热效应。近红外（NIR）光照射下，CPNs-G 产生局部热量以实现光热效应。同时，升高的温度增强了 GOx 的催化活性，从而阻止三磷酸腺苷（ATP）的生成并抑制 HSP 的表达。因此，这项工作提供了一种通过 NIR 光调控的酶介饥饿效应来克服耐热性的策略。
