Clin Lab. 2022 May 1;68(5). doi: 10.7754/Clin.Lab.2021.210720.
It is critical to determine the importance of laboratory tests on the mortality of Covid-19 disease. Our aim is to search the effect of D-dimer, C-reactive protein (CRP), ferritin, and lymphocyte count in the algorithm organized by our Ministry of Health in the diagnosis and treatment of Covid-19 on mortality.
Two hundred forty-five patients admitted to the emergency department (ED) with a diagnosis of Covid-19 pneumonia between March 15, 2020, and May 15, 2020. CRP, D-dimer, ferritin, and lymphocyte count included in the algorithm of the Ministry of Health. The relationship between demographic, clinical, and laboratory characteristics of the patients and their thirty-day mortality was examined.
A statistically significant difference was only found in coronary artery disease between the mortality rates and underlying diseases of the patients included in the study. When the diagnostic contribution of laboratory values to the mortality estimation was evaluated, the areas under the curve were the highest for CRP 0.782 (95% Cl 0.68 - 0.88), ferritin 0.740 (95% Cl 0.60 - 0.88), and D-dimer 0.738 (95% Cl 0.58 - 0.89).
An increased serum CRP, D-dimer, ferritin levels, and low lymphocyte count as shown by Turkish Ministry of Health in Turkey are significant predictors of COVID-19 mortality.
确定实验室检测对 COVID-19 疾病死亡率的重要性至关重要。我们的目的是研究土耳其卫生部诊断和治疗 COVID-19 方案中 D-二聚体、C 反应蛋白（CRP）、铁蛋白和淋巴细胞计数对死亡率的影响。
2020 年 3 月 15 日至 5 月 15 日期间，245 名因 COVID-19 肺炎被收入急诊科的患者。该方案中包含 CRP、D-二聚体、铁蛋白和淋巴细胞计数。研究检查了患者的人口统计学、临床和实验室特征与 30 天死亡率之间的关系。
仅在纳入研究的患者的基础疾病中发现冠心病与死亡率之间存在统计学显著差异。当评估实验室值对死亡率估计的诊断贡献时，CRP 的曲线下面积最高为 0.782（95%Cl 0.68-0.88），铁蛋白为 0.740（95%Cl 0.60-0.88），D-二聚体为 0.738（95%Cl 0.58-0.89）。
土耳其卫生部在土耳其显示的血清 CRP、D-二聚体、铁蛋白水平升高和淋巴细胞计数降低是 COVID-19 死亡率的显著预测因子。
