Torrecárdenas Hospital, 04009 Almería, Spain.
Department of Nursing, Physiotherapy and Medicine, University of Almeria, 04120 Almería, Spain.
Int J Environ Res Public Health. 2022 Apr 28;19(9):5354. doi: 10.3390/ijerph19095354.
Those infected by COVID-19 develop various kinds of complications with varying degrees of severity. For this reason, it is necessary to evaluate its analytical values to predict and reduce the risks and complications derived from this pathology. A cross-sectional study was carried out a population in Almeria (south-eastern Spain) who had a positive Polymerase Chain Reaction test result from 1 March 2020 to 30 November 2020. The study involved 4575 patients, with 1346 who were asymptomatic, 1653 mildly symptomatic (no hospitalisation needed) and 1576 severely symptomatic (symptomatic patients hospitalised). Laboratory values for D-dimer, glucose, serum ferritin, and C-reactive protein were analysed. The mean age of the participants in the study was 53.60 (16.89) years old. A total of 70.6% of the patients were symptomatic, of which 36.1% had mild symptoms. For all of the laboratory predictors analysed (D-dimer, glucose, serum ferritin, and C-reactive protein), it was found that severe alterations in the parameters were more frequent in severely symptomatic patients with statistically significant differences (p < 0.001), although these alterations also occurred in asymptomatic patients. Age correlated with analytical values (D-dimer, glucose, serum ferritin, and C-reactive protein) with statistically significant differences. Patients with severe symptoms presented alterations in the analytical values of D-dimer, glucose, serum ferritin, and C-reactive protein. Asymptomatic patients presented alterations in the analysed parameters, though with less frequency and severity than patients with severe symptoms.
感染 COVID-19 的患者会出现各种不同严重程度的并发症。因此，有必要评估其分析值，以预测和降低该病理学带来的风险和并发症。本研究为横断面研究，纳入了 2020 年 3 月 1 日至 11 月 30 日期间于西班牙东南部阿尔梅里亚（Almeria）进行过阳性聚合酶链反应（Polymerase Chain Reaction）检测的人群。共纳入 4575 例患者，其中 1346 例无症状，1653 例症状轻微（无需住院治疗），1576 例症状严重（症状患者住院治疗）。分析了 D-二聚体、血糖、血清铁蛋白和 C-反应蛋白的实验室值。研究参与者的平均年龄为 53.60（16.89）岁。70.6%的患者有症状，其中 36.1%为轻症。对于所有分析的实验室预测指标（D-二聚体、血糖、血清铁蛋白和 C-反应蛋白），严重症状患者的参数严重改变更为频繁，差异具有统计学意义（p < 0.001），尽管无症状患者也存在这些改变。年龄与分析值（D-二聚体、血糖、血清铁蛋白和 C-反应蛋白）相关，差异具有统计学意义。严重症状患者的 D-二聚体、血糖、血清铁蛋白和 C-反应蛋白分析值发生改变。无症状患者的分析参数也发生了改变，但严重程度和频率均低于严重症状患者。
