Clin Lab. 2022 May 1;68(5). doi: 10.7754/Clin.Lab.2021.210811.
Abnormal A Disintegrin and Metalloproteinase with Thrombospondin Motifs 2 (ADAMTS2) and V-set and immunoglobulin domain-containing 4 (VSIG4) were explored in serum of heart failure (HF) patients and its association with C-reactive protein (CRP), uric acid (UA), and homocysteine (HCY) indexes was manifested.
ADAMTS2 and VSIG4 expression in serum of HF patients was analyzed. Pearson's correlation coefficient analysis was employed to evaluate the correlation between the indexes. Receiver operating characteristic (ROC) curves to assess the recognition ability of ADAMTS2, VSIG4, and brain natriuretic peptide (BNP) for HF. Kaplan-Meier survival curve and multivariate Cox regression were applied to analyze the prognostic value of ADAMTS2 and VSIG4.
ADAMTS2 and VSIG4 were upregulated in serum of HF patients. ROC curve affirmed that ADAMTS2 and VSIG4 in serum manifested diagnostic value for HF, and the combined diagnosis accuracy of ADAMTS2, VSIG4, and BNP was greatly improved. Kaplan-Meier and multivariate Cox regression analysis suggested that reduced ADAMTS2 and VSIG4 could forecast the overall survival of HF patients.
This study assures that ADAMTS2 and VSIG4 are strengthening in HF patients, which makes them new non-invasive biomarkers for the diagnosis and prognosis of HF.
异常 A 型血小板反应蛋白 2（ADAMTS2）和 V 型免疫球蛋白结构域 4（VSIG4）在心力衰竭（HF）患者的血清中进行了探索，并表明其与 C 反应蛋白（CRP）、尿酸（UA）和同型半胱氨酸（HCY）指标相关。
分析 HF 患者血清中 ADAMTS2 和 VSIG4 的表达。采用 Pearson 相关系数分析评估各指标之间的相关性。绘制受试者工作特征（ROC）曲线评估 ADAMTS2、VSIG4 和脑钠肽（BNP）对 HF 的识别能力。采用 Kaplan-Meier 生存曲线和多因素 Cox 回归分析评估 ADAMTS2 和 VSIG4 的预后价值。
HF 患者血清中 ADAMTS2 和 VSIG4 呈上调表达。ROC 曲线证实，血清中 ADAMTS2 和 VSIG4 对 HF 具有诊断价值，且 ADAMTS2、VSIG4 和 BNP 的联合诊断准确性大大提高。Kaplan-Meier 和多因素 Cox 回归分析表明，ADAMTS2 和 VSIG4 的减少可预测 HF 患者的总体生存率。
本研究证实 ADAMTS2 和 VSIG4 在 HF 患者中增强，使其成为 HF 诊断和预后的新型非侵入性生物标志物。
