McIntyre K E
J Vasc Surg. 1987 May;5(5):787-90. doi: 10.1067/mva.1987.avs0050787b.
Newer culture techniques have demonstrated that diabetic foot infections are polymicrobial, involving both anaerobic and aerobic bacteria. These infections are characteristically foul-smelling and create immense tissue destruction. Occasionally, despite the absence of clostridial organisms, subcutaneous gas may be present. The importance of adequate surgical debridement has been emphasized. In the event of advancing, unremitting infection involving the foot, ankle guillotine amputation may be a life-saving technique. Finally, the role of host-defense mechanism in diabetes is important. Polymorphonuclear leukocyte chemotaxis and phagocytosis are energy-dependent processes that are deficient in the diabetic. Better diabetic control with maintenance of normal blood sugars and avoidance of ketoacidosis may be the key to prevention of these morbid, lower extremity infections.
更新的培养技术表明，糖尿病足感染是多微生物感染，涉及厌氧菌和好氧菌。这些感染的特征是有恶臭，并造成巨大的组织破坏。偶尔，即使没有梭菌属微生物，皮下也可能存在气体。充分的外科清创术的重要性已得到强调。如果足部感染进展且持续不愈，踝关节离断术可能是一种挽救生命的技术。最后，宿主防御机制在糖尿病中的作用很重要。多形核白细胞趋化和吞噬是能量依赖过程，糖尿病患者存在缺陷。更好地控制糖尿病，维持正常血糖水平并避免酮症酸中毒，可能是预防这些严重的下肢感染的关键。
