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Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia.

作者信息

Carlos Arenn F, Tosakulwong Nirubol, Weigand Stephen D, Boeve Bradley F, Knopman David S, Petersen Ronald C, Nguyen Aivi, Reichard R Ross, Murray Melissa E, Dickson Dennis W, Josephs Keith A

机构信息

Department of Neurology, Mayo Clinic, 200 1st St S.W., Rochester, MN, 55905, USA.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

出版信息

Acta Neuropathol. 2022 Jul;144(1):159-160. doi: 10.1007/s00401-022-02434-3. Epub 2022 May 10.

DOI:10.1007/s00401-022-02434-3
PMID:35536384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9943023/
Abstract
摘要

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1
Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia.在一大群有或没有痴呆症的老年人中，TAR DNA结合蛋白43（TDP - 43）病理改变的频率和分布随年龄呈线性增加。
Acta Neuropathol. 2022 Jul;144(1):159-160. doi: 10.1007/s00401-022-02434-3. Epub 2022 May 10.
2
TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes.TDP-43 蛋白病：区分临床表型的大脑区域的病理学鉴定。
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[Neuropathology of TDP-43 proteinopathy].[TDP-43蛋白病的神经病理学]
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TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features.TAR DNA结合蛋白43与阿尔茨海默病的病理亚型影响临床特征。
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5
TDP-43 Related Neuropathologies and Phosphorylation State: Associations with Age and Clinical Dementia in the Cambridge City over-75s Cohort.TDP-43 相关神经病理学和磷酸化状态：与剑桥市 75 岁以上人群队列的年龄和临床痴呆的关联。
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6
Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43.泛素化、p62 免疫阳性的小脑皮质神经元包含物在 TDP-43 蛋白病谱中均可见，但仅偶尔对磷酸化依赖的 TDP-43 也呈免疫阳性。
Neuropathology. 2011 Jun;31(3):239-49. doi: 10.1111/j.1440-1789.2010.01171.x. Epub 2010 Dec 1.
7
Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons.TDP-43 病理学与老年人特定领域文化程度的关联。
Alzheimer Dis Assoc Disord. 2019 Oct-Dec;33(4):315-320. doi: 10.1097/WAD.0000000000000334.
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Could Lifetime Lead Exposure Play a Role in Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)?终生接触铅会在边缘为主的与年龄相关的 TDP-43 脑病（LATE）中起作用吗？
J Alzheimers Dis. 2020;73(2):455-459. doi: 10.3233/JAD-190943.
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Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis.创伤性脑损伤会导致额颞叶痴呆和TDP-43蛋白水解。
Neuroscience. 2015 Aug 6;300:94-103. doi: 10.1016/j.neuroscience.2015.05.013. Epub 2015 May 14.
10
[A new dementia group caused by TDP-43 abnormality].[由TDP-43异常引起的新型痴呆症组]
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Relation of Alzheimer's disease-related TDP-43 proteinopathy to metrics from diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI).阿尔茨海默病相关的TDP-43蛋白病与扩散张量成像（DTI）及神经突方向离散度和密度成像（NODDI）指标的关系。
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White matter hyperintensities and TDP-43 pathology in Alzheimer's disease.阿尔茨海默病中的白质高信号与TDP-43病理学
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Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy.边缘叶为主的年龄相关性TDP-43脑病的临床标准。
Alzheimers Dement. 2025 Jan;21(1):e14202. doi: 10.1002/alz.14202. Epub 2025 Jan 14.
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Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis.以边缘系统为主的与年龄相关的 TDP-43 脑病（LATE-NC）：共病和遗传风险因素为发病机制提供线索。
J Neuropathol Exp Neurol. 2024 May 22;83(6):396-415. doi: 10.1093/jnen/nlae032.
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J Int Neuropsychol Soc. 2024 Jul;30(6):575-583. doi: 10.1017/S1355617724000146. Epub 2024 Mar 25.
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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.一种短暂的蛋白质折叠反应在TDP - 43介导的神经退行性变早期针对聚集物。
Nat Commun. 2024 Feb 19;15(1):1508. doi: 10.1038/s41467-024-45646-9.
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Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease.STMN2 和 UNC13A mRNA 的剪接异常是 TDP-43 相关阿尔茨海默病的病理特征。
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Clinicopathologic features of a novel star-shaped transactive response DNA-binding protein 43 (TDP-43) pathology in the oldest old.最年长人群中新型星形 TDP-43（转导反应 DNA 结合蛋白 43）病理学的临床病理特征。
J Neuropathol Exp Neurol. 2023 Dec 22;83(1):36-52. doi: 10.1093/jnen/nlad105.
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Senile plaque-associated transactive response DNA-binding protein 43 in Alzheimer's disease: A case report spanning 16 years of memory loss.阿尔茨海默病中与老年斑相关的转导反应 DNA 结合蛋白 43：跨越 16 年记忆丧失的病例报告。
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本文引用的文献

1
Association between transactive response DNA-binding protein of 43 kDa type and cognitive resilience to Alzheimer's disease: a case-control study.43kDa 型交互反应 DNA 结合蛋白与阿尔茨海默病认知弹性的关系：一项病例对照研究。
Neurobiol Aging. 2020 Aug;92:92-97. doi: 10.1016/j.neurobiolaging.2020.04.001. Epub 2020 Apr 15.
2
Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains.病理学、影像学和遗传学特征支持在非额颞叶痴呆大脑中存在不同的 TDP-43 类型。
Acta Neuropathol. 2019 Feb;137(2):227-238. doi: 10.1007/s00401-018-1951-7. Epub 2019 Jan 2.
3
Updated TDP-43 in Alzheimer's disease staging scheme.阿尔茨海默病分期方案中更新的TDP-43。
Acta Neuropathol. 2016 Apr;131(4):571-85. doi: 10.1007/s00401-016-1537-1. Epub 2016 Jan 25.
4
TDP-43 pathology, cognitive decline, and dementia in old age.老年 TDP-43 病理学、认知能力下降与痴呆。
JAMA Neurol. 2013 Nov;70(11):1418-24. doi: 10.1001/jamaneurol.2013.3961.