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Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia.

作者信息

Carlos Arenn F, Tosakulwong Nirubol, Weigand Stephen D, Boeve Bradley F, Knopman David S, Petersen Ronald C, Nguyen Aivi, Reichard R Ross, Murray Melissa E, Dickson Dennis W, Josephs Keith A

机构信息

Department of Neurology, Mayo Clinic, 200 1st St S.W., Rochester, MN, 55905, USA.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

出版信息

Acta Neuropathol. 2022 Jul;144(1):159-160. doi: 10.1007/s00401-022-02434-3. Epub 2022 May 10.

Abstract
摘要

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Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains.
Acta Neuropathol. 2019 Feb;137(2):227-238. doi: 10.1007/s00401-018-1951-7. Epub 2019 Jan 2.
3
Updated TDP-43 in Alzheimer's disease staging scheme.
Acta Neuropathol. 2016 Apr;131(4):571-85. doi: 10.1007/s00401-016-1537-1. Epub 2016 Jan 25.
4
TDP-43 pathology, cognitive decline, and dementia in old age.
JAMA Neurol. 2013 Nov;70(11):1418-24. doi: 10.1001/jamaneurol.2013.3961.

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