微小 RNA 调控破骨细胞介导的骨吸收。
Regulation of osteoclast-mediated bone resorption by microRNA.
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
出版信息
Cell Mol Life Sci. 2022 May 10;79(6):287. doi: 10.1007/s00018-022-04298-y.
Abstract
Osteoclast-mediated bone resorption is responsible for bone metabolic diseases, negatively impacting people's health and life. It has been demonstrated that microRNA influences the differentiation of osteoclasts by regulating the signaling pathways during osteoclast-mediated bone resorption. So far, the involved mechanisms have not been fully elucidated. This review introduced the pathways involved in osteoclastogenesis and summarized the related microRNAs binding to their specific targets to mediate the downstream pathways in osteoclast-mediated bone resorption. We also discuss the clinical potential of targeting microRNAs to treat osteoclast-mediated bone resorption as well as the challenges of avoiding potential side effects and producing efficient delivery methods.
摘要
破骨细胞介导的骨吸收是导致骨代谢疾病的原因，对人们的健康和生活造成负面影响。已经证明，microRNA 通过调节破骨细胞介导的骨吸收过程中的信号通路来影响破骨细胞的分化。到目前为止，其涉及的机制尚未完全阐明。本综述介绍了破骨细胞生成过程中涉及的途径，并总结了相关的 microRNA 与其特定靶标结合，从而介导破骨细胞介导的骨吸收下游途径的相关内容。我们还讨论了针对 microRNA 治疗破骨细胞介导的骨吸收的临床潜力，以及避免潜在副作用和产生有效递送方法的挑战。
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