Tsaltskan Vladislav, Nguyen Katherine, Eaglin Christina, Holers V Michael, Deane Kevin D, Firestein Gary S
University of California, San Diego, La Jolla.
University of Colorado Denver, Aurora.
ACR Open Rheumatol. 2022 Jul;4(7):623-630. doi: 10.1002/acr2.11448. Epub 2022 May 10.
Traditional nondigital methods of participant recruitment for clinical research studies in rheumatology can be costly and inefficient, particularly for recruitment of underserved populations. We aimed to address this need by evaluating two methods of online recruitment to an observational cohort of individuals at risk for rheumatoid arthritis, namely web and Facebook advertisements.
A 3-month countywide web-based recruitment campaign was conducted consisting of text and image-based advertisements. Similar advertisements were subsequently displayed on Facebook, initially in English for 5 months and later in Spanish for an additional 3 months. Individuals who clicked on advertisements were directed to a website landing page containing study information and could contact study personnel to schedule testing for anti-cyclic citrullinated peptide-3 (CCP3). The primary outcome measure for each campaign was the click-through rate.
During the web campaign, 413,289 advertisement impressions were displayed, resulting in 428 clicks (click-through rate 0.10%) and only one screened participant. During the English Facebook campaign, 724,815 advertisements were displayed with 6765 clicks (click-through rate 0.93%) and 43 screened participants, significantly greater than the web campaign (P < 0.001). During the Spanish advertisement campaign, 255,730 Spanish advertisements were displayed, resulting in a click-through rate of 2.09% and 24 screened participants, a significantly higher rate than English advertisements. Of participants recruited through social media, 94% were female and 29.8% were Spanish speakers.
Facebook advertisements were superior to web advertisements for participant recruitment. Spanish Facebook advertisements had a greater click-through rate than English Facebook advertisements. Facebook was an effective recruitment method, particularly for Spanish speakers.
在风湿病临床研究中，传统的非数字式受试者招募方法可能成本高昂且效率低下，尤其是在招募服务不足人群时。我们旨在通过评估两种在线招募方法来满足这一需求，这两种方法针对的是类风湿关节炎高危个体的观察性队列，即网络广告和脸书广告。
开展了一项为期3个月的全县范围基于网络的招募活动，包括基于文本和图像的广告。随后，类似的广告在脸书上展示，最初用英语展示5个月，之后用西班牙语再展示3个月。点击广告的个体被引导至一个包含研究信息的网站着陆页，他们可以联系研究人员安排抗环瓜氨酸肽-3（CCP3）检测。每次活动的主要结果指标是点击率。
在网络活动期间，展示了413,289次广告展示量，产生了428次点击（点击率0.10%），仅有一名受试者通过筛查。在脸书英语活动期间，展示了724,815次广告，有6765次点击（点击率0.93%），43名受试者通过筛查，显著高于网络活动（P < 0.001）。在西班牙语广告活动期间，展示了255,730次西班牙语广告，点击率为2.09%，24名受试者通过筛查，该比率显著高于英语广告。通过社交媒体招募的受试者中，94%为女性，29.8%说西班牙语。
在受试者招募方面，脸书广告优于网络广告。西班牙语脸书广告的点击率高于英语脸书广告。脸书是一种有效的招募方法，尤其对于说西班牙语的人群。
