基于 OCT 血管造影的黄斑新生血管检测的中心性浆液性脉络膜视网膜病变的风险因素和特征：一项回顾性多中心观察研究。

Risk factors and characteristics of central serous chorioretinopathy with later development of macular neovascularisation detected on OCT angiography: a retrospective multicentre observational study.

机构信息

Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Japan Clinical Retina Study (JCREST) group, Kagoshima, Kagoshima, Japan.

出版信息

BMJ Open Ophthalmol. 2022 Apr;7(1). doi: 10.1136/bmjophth-2022-000976.

DOI:10.1136/bmjophth-2022-000976

PMID:35537029

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9016399/

Abstract

OBJECTIVE

To identify the risk factors and characteristics of central serous chorioretinopathy (CSC) with subsequent macular neovascularisation (MNV) detected on optical coherence tomography angiography (OCTA).

METHODS AND ANALYSIS

We included patients from six institutions who were initially diagnosed with CSC and subsequently did or did not develop MNV detected by OCTA. Potential influencing factors were identified by evaluating the patients' baseline demographics, multimodal fundus imaging, treatment options, recurrence and outcomes in both groups.

RESULTS

We enrolled 176 eyes in 152 patients (112 men, 40 women; mean age: 52.1±10.4 years) with a mean follow-up of 30.4±16.3 months. Secondary MNV was present in 23 eyes (13.1%), and non-MNV was observed in 153 eyes (86.9%) by OCTA. Multivariate analysis revealed that older age (OR 1.06; 95% CI 1.01 to 1.11; p=0.014), chronic CSC (OR 3.05; 95% CI 1.12 to 8.30; p=0.029), leakage sites within the fovea on fluorescein angiography (OR 7.60; 95% CI, 1.89 to 30.48; p=0.004) and recurrent fluid within the first year (OR 5.12; 95% CI 1.66 to 15.77; p=0.012) were risk factors for subsequent MNV. Moreover, eyes with CSC complicated with MNV were characterised by poor visual acuity and low complete fluid resolution rates.

CONCLUSION

The factors associated with MNV secondary to CSC were older age, higher rates of chronic CSC and recurrence, and foveal leakage points on fluorescein angiography.

摘要

目的

确定光学相干断层扫描血管造影（OCTA）检测到的中心性浆液性脉络膜视网膜病变（CSC）继发黄斑新生血管（MNV）的危险因素和特征。

方法与分析

我们纳入了来自六家机构的患者，这些患者最初被诊断为 CSC，随后通过 OCTA 检测出是否存在 MNV。通过评估两组患者的基线人口统计学、多模态眼底成像、治疗选择、复发和结局，确定潜在的影响因素。

结果

我们纳入了 152 例患者的 176 只眼（男性 112 例，女性 40 例；平均年龄：52.1±10.4 岁），平均随访 30.4±16.3 个月。23 只眼（13.1%）出现继发性 MNV，153 只眼（86.9%）通过 OCTA 观察到非 MNV。多变量分析显示，年龄较大（OR 1.06；95%CI 1.01 至 1.11；p=0.014）、慢性 CSC（OR 3.05；95%CI 1.12 至 8.30；p=0.029）、荧光素血管造影中黄斑区内渗漏点（OR 7.60；95%CI，1.89 至 30.48；p=0.004）和第一年复发的液体积聚（OR 5.12；95%CI 1.66 至 15.77；p=0.012）是继发黄斑 MNV 的危险因素。此外，伴有 MNV 的 CSC 眼视力较差，完全液体消退率较低。