Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, SO16 6YD, United Kingdom.
NIHR Moorfields Biomedical Research Centre, 162, City Road, London, EC1V 2PD, United Kingdom.
Prog Retin Eye Res. 2020 Nov;79:100865. doi: 10.1016/j.preteyeres.2020.100865. Epub 2020 May 11.
Central serous chorioretinopathy (CSC) is a common form of vision loss, typically seen in working-age men. The pathophysiology behind CSC still eludes us, however significant advances have been made in understanding this disease over the last decade using information from genetic and cell-based studies and imaging modalities. This review aims to give an overview of the current pathophysiology hypotheses surrounding CSC in addition to future directions in cellular work from human induced pluripotent stem cell derived choroidal endothelial cells from CSC patients. Furthermore, this review will provide the reader with an update on the clinical aspects of CSC including risk factors, diagnostic challenges and findings from multimodal imaging.
中心性浆液性脉络膜视网膜病变（CSC）是一种常见的视力丧失形式，通常发生在工作年龄的男性中。然而，CSC 的病理生理学仍然让我们感到困惑，但是在过去十年中，通过遗传和基于细胞的研究以及成像方式的信息，我们在理解这种疾病方面取得了重大进展。本综述旨在概述目前围绕 CSC 的病理生理学假设，以及来自 CSC 患者诱导多能干细胞衍生脉络膜内皮细胞的细胞工作的未来方向。此外，本综述将为读者提供有关 CSC 的临床方面的最新信息，包括危险因素、诊断挑战以及多模态成像的结果。
