Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.
Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Chem Res Toxicol. 2022 Jun 20;35(6):935-939. doi: 10.1021/acs.chemrestox.2c00087. Epub 2022 May 10.
Human three-prime repair exonuclease 1 (TREX1) is the major 3' to 5' exonuclease that functions to deplete the cytosolic DNA to prevent the autoimmune response. TREX1 is upregulated and translocates from cytoplasm to the nucleus in response to genotoxic stress, but the function of nuclear TREX1 is not well understood. Herein, we wish to report our finding that TREX1 efficiently excises 3'-phospho-α,β-unsaturated aldehyde and 3'-deoxyribose phosphate that are commonly produced as base excision repair intermediates and also from the nonenzymatic strand incision at abasic sites.
人类 3′端修复外切核酸酶 1（TREX1）是主要的 3′到 5′外切核酸酶，其功能是耗尽细胞质 DNA，以防止自身免疫反应。TREX1 在外源遗传毒性应激下上调并从细胞质易位到细胞核，但核 TREX1 的功能尚不清楚。在此，我们报告了我们的发现，即 TREX1 有效地切除了 3′-磷酸-α，β-不饱和醛和 3′-脱氧核糖磷酸，这些物质通常作为碱基切除修复中间体产生，也可以从无碱基位点的非酶切链断裂中产生。
