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2
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Synthesis and Excision Repair of Site-Specific 3'-End DNA-Histone Cross-Links Derived from Abasic Sites.碱基切除修复合成与特定 3'-末端 DNA-组蛋白交联物的切除。
Bioconjug Chem. 2023 Jun 21;34(6):983-987. doi: 10.1021/acs.bioconjchem.3c00156. Epub 2023 May 15.
2
PARP1 Incises Abasic Sites and Covalently Cross-links to 3'-DNA Termini via Cysteine Addition Not Reductive Amination.PARP1通过添加半胱氨酸而非还原胺化作用切割无碱基位点并与3'-DNA末端共价交联。
Biochemistry. 2023 May 16;62(10):1527-1530. doi: 10.1021/acs.biochem.3c00138. Epub 2023 Apr 24.
3
DNA-protein cross-links between abasic DNA damage and mitochondrial transcription factor A (TFAM).碱基切除修复过程中形成的 DNA-蛋白质交联与线粒体转录因子 A（TFAM）之间的关系。
Nucleic Acids Res. 2023 Jan 11;51(1):41-53. doi: 10.1093/nar/gkac1214.
4
Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase.主要氧化损伤 7,8-二氢-8-氧鸟嘌呤在催化有效 DNA 糖苷酶中的结构。
Biochem J. 2022 Nov 11;479(21):2297-2309. doi: 10.1042/BCJ20220438.
5
Tyrosyl-DNA phosphodiesterase 1 excises the 3'-DNA-ALKBH1 cross-link and its application for 3'-DNA-ALKBH1 cross-link characterization by LC-MS/MS.酪氨酸-DNA 磷酸二酯酶 1 切除 3'-DNA-ALKBH1 交联及其在 LC-MS/MS 分析 3'-DNA-ALKBH1 交联中的应用。
DNA Repair (Amst). 2022 Nov;119:103391. doi: 10.1016/j.dnarep.2022.103391. Epub 2022 Aug 27.
6
Reconsidering the Chemical Nature of Strand Breaks Derived from Abasic Sites in Cellular DNA: Evidence for 3'-Glutathionylation.重新考虑源自细胞 DNA 无碱基位点的链断裂的化学本质：3'-谷胱甘肽化的证据。
J Am Chem Soc. 2022 Jun 15;144(23):10471-10482. doi: 10.1021/jacs.2c02703. Epub 2022 May 25.
7
Human TREX1 Repairs 3'-End DNA Lesions .人类 TREX1 修复 3'-末端 DNA 损伤。
Chem Res Toxicol. 2022 Jun 20;35(6):935-939. doi: 10.1021/acs.chemrestox.2c00087. Epub 2022 May 10.
8
Human TDP1, APE1 and TREX1 repair 3'-DNA-peptide/protein cross-links arising from abasic sites in vitro.人类 TDP1、APE1 和 TREX1 修复体外无碱基位点产生的 3'-DNA-肽/蛋白交联。
Nucleic Acids Res. 2022 Apr 22;50(7):3638-3657. doi: 10.1093/nar/gkac185.
9
Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site.脱嘌呤/脱嘧啶内切酶1和酪氨酰-DNA磷酸二酯酶1可防止脱嘌呤/脱嘧啶位点处的自杀性共价DNA-蛋白质交联。
Front Cell Dev Biol. 2021 Jan 11;8:617301. doi: 10.3389/fcell.2020.617301. eCollection 2020.
10
New insights into abasic site repair and tolerance.碱基切除修复与耐受的新见解
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人类8-氧代鸟嘌呤糖基化酶OGG1切割无碱基位点并通过添加半胱氨酸和组氨酸与3'-DNA末端共价结合。

Human 8-Oxoguanine Glycosylase OGG1 Cleaves Abasic Sites and Covalently Conjugates to 3'-DNA Termini via Cysteine and Histidine Addition.

作者信息

Bryan Cameron, Yang Kun

机构信息

Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas, 78712, United States.

出版信息

Chembiochem. 2025 Jan 14;26(2):e202400705. doi: 10.1002/cbic.202400705. Epub 2024 Nov 11.

DOI:10.1002/cbic.202400705
PMID:39387674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11779587/
Abstract

8-Oxoguanine glycosylase 1 (OGG1) repairs the major oxidative DNA damage, 8-oxo-2'-deoxyguanosine. It has been reported that OGG1 incises the most frequently formed DNA lesion, apurinic/apyrimidinic (AP) site, and in the process a stable DNA-OGG1 cross-link is formed. However, the chemical structure of the adduct is not characterized. Here, we report that DNA-OGG1 cross-links result from cysteine and histidine addition to incised AP sites at 3'-DNA termini.

摘要

8-氧代鸟嘌呤糖基化酶1（OGG1）修复主要的氧化性DNA损伤——8-氧代-2'-脱氧鸟苷。据报道，OGG1能切割最常见形成的DNA损伤——无嘌呤/无嘧啶（AP）位点，并且在此过程中会形成稳定的DNA-OGG1交联。然而，该加合物的化学结构尚未得到表征。在此，我们报告DNA-OGG1交联是由半胱氨酸和组氨酸添加到3'-DNA末端切割后的AP位点所导致的。