Odaman Al Işik, Demirağ Bengü, Erdem Melek, Genç Sinan, Karapinar Tuba H
Departments of Pediatric Hematology and Oncology.
Pediatric Radyology, Dr Behcet Uz Traning and Research Hospital, İzmir, Turkey.
J Pediatr Hematol Oncol. 2023 Mar 1;45(2):e259-e265. doi: 10.1097/MPH.0000000000002472. Epub 2022 May 5.
Hepatic hemangiomas (HH) are the most common vascular tumors of the liver. It is important to distinguish hemangiomas from malignant liver tumors.
The patients 0 to 1 years old, were diagnosed with HH and followed up in the oncology outpatient clinic between 2009 and 2020 were included in the study.
A total of 127 patients with the diagnosis of HH were included in the study. Of the patients, 99 (78%) had focal, 20 (15.7%) had multifocal, and 8 (6.3%) had diffuse HHs. Surgery was performed and the diagnosis was confirmed histopathologically in 6 patients (4.7%). During the follow-up, 16 (12.5%) patients received medical treatment. Thirteen (10.2%) were treated with propranolol, 2 (1.5%) with corticosteroids, and 1 (0.8%) with propranolol and corticosteroids. Complete response was obtained in 9 (9/16) patients and partial response was obtained in 6 (6/16) patients with medical treatment.
Although HH is a benign tumor, it is important to make its differential diagnosis with malignant tumors of the liver. Over the years, the need for histopathologic examination for diagnosis has decreased. The success rate of propranolol is high, and the need for other treatment options with a high side-effect profile has decreased significantly since 2008.
肝血管瘤（HH）是肝脏最常见的血管肿瘤。将血管瘤与肝脏恶性肿瘤区分开来很重要。
纳入2009年至2020年间在肿瘤门诊被诊断为HH并接受随访的0至1岁患者。
共有127例诊断为HH的患者纳入研究。其中，99例（78%）为局灶性，20例（15.7%）为多灶性，8例（6.3%）为弥漫性HH。6例患者（4.7%）接受了手术，组织病理学确诊。随访期间，16例（12.5%）患者接受了药物治疗。13例（10.2%）接受普萘洛尔治疗，2例（1.5%）接受皮质类固醇治疗，1例（0.8%）接受普萘洛尔和皮质类固醇联合治疗。药物治疗的患者中，9例（9/16）获得完全缓解，6例（6/16）获得部分缓解。
虽然HH是一种良性肿瘤，但将其与肝脏恶性肿瘤进行鉴别诊断很重要。多年来，诊断所需的组织病理学检查需求有所下降。普萘洛尔的成功率很高，自2008年以来，对其他副作用大的治疗选择的需求已显著减少。
