Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy.
J Org Chem. 2023 Apr 21;88(8):5180-5186. doi: 10.1021/acs.joc.2c00686. Epub 2022 May 10.
A palladium-catalyzed carbonylative approach to benzothiophene-3-carboxylic esters, starting from simple and readily available building blocks [2-(methylthio)phenylacetylenes, CO, an alcohol, and O (from air)], is reported. The process is catalyzed by the simple PdI/KI catalytic system to give the desired products in fair to high yields (57-83%). Interestingly, the reaction also works nicely in the ionic liquid BmimBF as the solvent, with the possibility to recycle the catalytic system several times without appreciable loss of activity.
报道了一种钯催化的羰基化方法，用于从简单易得的起始原料[2-(甲硫基)苯乙炔、CO、醇和 O（来自空气）]合成苯并噻吩-3-羧酸酯。该过程由简单的 PdI/KI 催化体系催化，以中等至较高的收率（57-83%）得到所需产物。有趣的是，该反应在离子液体 BmimBF 中也能很好地进行，并且有可能多次回收催化体系而活性没有明显损失。
