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一例单次使用依他酮中毒致死:临床症状与定量分析结果。

A fatal case of intoxication from a single use of eutylone: Clinical symptoms and quantitative analysis results.

机构信息

Department of Legal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520-2192, Japan.

出版信息

Leg Med (Tokyo). 2022 Sep;58:102085. doi: 10.1016/j.legalmed.2022.102085. Epub 2022 May 2.

Abstract

Eutylone is a synthetic cathinone that is becoming an increasingly popular drug in the US and Europe. This report describes a fatal case of eutylone intoxication. A 32-year-old man went into cardiac arrest after several minutes of abnormal behavior. Rectal temperature was 37.0 °C at 5 h after death. Autopsy revealed no remarkable injuries apart from several small abrasions and no signs of rhabdomyolysis. Toxicological examination revealed only aripiprazole in the therapeutic range and eutylone. The eutylone concentration in cardiac blood was 4290 ng/g. This case is valuable because it involved fatal intoxication from a single use of eutylone and quantitative analysis, whereas most previous reports of eutylone intoxication have involved a mixture of drugs with limited quantitative analysis.

摘要

依他酮是一种人工合成的卡西酮,在美国和欧洲正变得越来越流行。本报告描述了一例依他酮中毒的致死病例。一名 32 岁男子在出现异常行为几分钟后心脏骤停。死亡后 5 小时直肠温度为 37.0°C。尸检除了有几处小擦伤外,没有明显的损伤,也没有横纹肌溶解的迹象。毒理学检查仅显示在治疗范围内的阿立哌唑和依他酮。心脏血液中的依他酮浓度为 4290ng/g。本病例很有价值,因为它涉及到单次使用依他酮和定量分析导致的致命中毒,而以前大多数关于依他酮中毒的报告都涉及到混合药物且定量分析有限。

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