Baig Muhammad Usman, Madden Kevin, Moody Karen
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Loma Linda University, Loma Linda, California, USA.
Division of Cancer Medicine, Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
J Palliat Med. 2022 Dec;25(12):1884-1887. doi: 10.1089/jpm.2021.0526. Epub 2022 May 10.
Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.
度洛西汀适用于治疗成人化疗引起的神经性疼痛。它也适用于治疗儿童的焦虑、抑郁和纤维肌痛。成人中曾报告过一种罕见的抗利尿激素分泌异常综合征（SIADH）副作用，但儿科或儿科肿瘤患者中未出现过。我们报告一例10岁急性淋巴细胞白血病患儿，在给予度洛西汀治疗化疗引起的神经性疼痛和共病焦虑后发生了SIADH。停用度洛西汀后，SIADH症状缓解。该病例凸显了度洛西汀的一种罕见副作用，给儿童开度洛西汀时应谨慎。
