Zheng An-Ran, Wei Chao-Kun, Ni Zhi-Jing, Thakur Kiran, Zhang Jian-Guo, Wei Zhao-Jun
School of Food and Wine, Ningxia University, Yinchuan, 750021, People's Republic of China; School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, People's Republic of China.
School of Food and Wine, Ningxia University, Yinchuan, 750021, People's Republic of China; School of Biological Science and Engineering, Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, North Minzu University, Yinchuan, 750021, People's Republic of China; School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China.
Food Chem Toxicol. 2022 Jul;165:113115. doi: 10.1016/j.fct.2022.113115. Epub 2022 May 7.
Our study aimed to understand the effects of Maillard reaction products (MRPs) intake on intestinal health, in vitro digestion, and fermentation metabolites in Sprague-Dawley (SD) rats. MRPs promoted the digestion of pepsin, but was not conducive to the subsequent in vitro digestion of trypsin. MRPs ingestion increased the propionate in intestine, but it could not change the branched-chain fatty acids (BCFAs) and short-chain fatty acids (SCFAs). However, MRPs ingestion led to an increase in the Lactobacillus abundance in gut. In the high-dose groups, the abundance of genes in partial amino acid and monosaccharide metabolism increased, while in lipid metabolism decreased compared with the middle dose groups. Therefore, the absorption of MRPs was lowered than that of protein and carbohydrates. Through functional predictive analysis, our study could reveal the effects of long-term intake of MRPs on intestinal health in SD rats.
我们的研究旨在了解美拉德反应产物（MRPs）摄入对斯普拉格-道利（SD）大鼠肠道健康、体外消化及发酵代谢产物的影响。MRPs促进了胃蛋白酶的消化，但不利于随后胰蛋白酶的体外消化。摄入MRPs会增加肠道中的丙酸，但不会改变支链脂肪酸（BCFAs）和短链脂肪酸（SCFAs）。然而，摄入MRPs会导致肠道中乳酸杆菌丰度增加。在高剂量组中，与中剂量组相比，部分氨基酸和单糖代谢相关基因的丰度增加，而脂质代谢相关基因的丰度降低。因此，MRPs的吸收率低于蛋白质和碳水化合物。通过功能预测分析，我们的研究能够揭示长期摄入MRPs对SD大鼠肠道健康的影响。
