Department of Ophthalmology, Northwestern University, Chicago, Illinois, USA.
Department of Ophthalmology, Duke University, Durham, North Carolina, USA.
Br J Ophthalmol. 2023 Sep;107(9):1269-1274. doi: 10.1136/bjophthalmol-2021-320734. Epub 2022 May 10.
BACKGROUND/AIMS: To evaluate the association between statin use and rates of standard automated perimetry (SAP) and retinal nerve fibre layer (RNFL) change in patients with glaucoma and glaucoma suspects.
This retrospective cohort study included subjects from the Duke Glaucoma Registry with primary open-angle glaucoma and glaucoma suspects. Subjects were assigned to groups according to history of statin use. Rates of change in SAP mean deviation (MD) and spectral-domain optical coherence tomography (SD OCT) RNFL thickness over time were estimated using linear mixed models and compared in the statin versus control groups. The effect of duration of statin use was also assessed. Patients with glaucoma versus suspects were analysed separately. Analyses were adjusted for potential confounding factors of age, gender, race, intraocular pressure and follow-up time.
The study included 10 049 SAP tests and 14 198 SD OCT tests from 3007 eyes (1978 patients) followed for an average of 4.7±2.0 years. Of these, 775 subjects (1179 eyes) had a history of statin use. No difference in rates of change was seen between the statin versus control groups for MD (-0.07±0.16 dB/year vs -0.07±0.15 dB/year; p=0.873, respectively) or RNFL thickness (-0.70±0.60 µm/year vs -0.70±0.61 µm/year; p=0.923, respectively). Multivariable models controlling for potential confounders showed no significant association between duration of statin use and rates of MD or RNFL thickness change.
We did not find a statistically significant association between statin use or duration of statin use and rates of structural and functional change in those with glaucoma or glaucoma suspects.
背景/目的：评估他汀类药物使用与青光眼和疑似青光眼患者标准自动视野计（SAP）和视网膜神经纤维层（RNFL）变化率之间的关系。
本回顾性队列研究纳入了杜克青光眼登记处的原发性开角型青光眼和疑似青光眼患者。根据他汀类药物使用史将受试者分为两组。使用线性混合模型估计 SAP 平均偏差（MD）和光谱域光学相干断层扫描（SD OCT）RNFL 厚度随时间的变化率，并在他汀类药物组与对照组之间进行比较。还评估了他汀类药物使用持续时间的影响。分别分析青光眼患者与疑似青光眼患者。分析调整了年龄、性别、种族、眼压和随访时间等潜在混杂因素的影响。
本研究纳入了 3007 只眼（1978 例患者）的 10049 次 SAP 检查和 14198 次 SD OCT 检查，平均随访时间为 4.7±2.0 年。其中，775 例（1179 只眼）有他汀类药物使用史。他汀类药物组与对照组之间的 MD（-0.07±0.16 dB/年与-0.07±0.15 dB/年；p=0.873）或 RNFL 厚度（-0.70±0.60 µm/年与-0.70±0.61 µm/年；p=0.923）变化率无差异。控制潜在混杂因素的多变量模型显示，他汀类药物使用持续时间与 MD 或 RNFL 厚度变化率之间无显著关联。
我们未发现他汀类药物使用或使用持续时间与青光眼或疑似青光眼患者结构和功能变化率之间存在统计学显著关联。
