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对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染如何引发细胞因子风暴的见解。

Insights into how SARS-CoV2 infection induces cytokine storms.

作者信息

Selva Kevin John, Chung Amy W

机构信息

Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

出版信息

Trends Immunol. 2022 Jun;43(6):417-419. doi: 10.1016/j.it.2022.04.007. Epub 2022 May 7.

DOI:10.1016/j.it.2022.04.007
PMID:35537983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077489/
Abstract

Severe coronavirus disease 2019 (COVID-19) has been associated with cytokine storms and hyperinflammation. In a recent study, Junqueira et al. provide evidence that antibody-mediated uptake of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus by monocytes and macrophages may contribute to this inflammation by activating inflammasomes which trigger pyroptosis.

摘要

2019年冠状病毒病（COVID-19）重症病例与细胞因子风暴及过度炎症反应有关。在最近一项研究中，容凯拉等人提供的证据表明，单核细胞和巨噬细胞通过抗体介导摄取严重急性呼吸综合征冠状病毒2（SARS-CoV-2），可能会激活炎性小体引发细胞焦亡，从而导致这种炎症反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b7/9077489/cda3803015ea/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b7/9077489/cda3803015ea/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28b7/9077489/cda3803015ea/gr1_lrg.jpg

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Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity.早期非中和性、去岩藻糖基化抗体反应与 COVID-19 严重程度相关。
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The Roles of Gasdermin D in Coronavirus Infection and Evasion.Gasdermin D在冠状病毒感染与逃逸中的作用
整合转录组学、表达定量性状基因座（eQTL）和孟德尔随机化以剖析单核细胞在重症 COVID-19 和痛风发作中的作用。
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Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases.白细胞介素-6在严重急性呼吸综合征冠状病毒2感染和心脏代谢疾病中的不同作用
Cardiol Discov. 2023 Sep;3(3):166-182. doi: 10.1097/CD9.0000000000000096. Epub 2023 Jul 27.
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