Department of Environmental Health, Program in Molecular and Integrative Physiological Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Transl Psychiatry. 2022 May 10;12(1):193. doi: 10.1038/s41398-022-01948-4.
Little is known about the genetics of norm violation and aggression in relation to coronavirus disease 2019 (COVID-19). To investigate this, we used summary statistics from genome-wide association studies and linkage disequilibrium score regression to calculate a matrix of genetic correlations (r) for antisocial behavior (ASB), COVID-19, and various health and behavioral traits. After false-discovery rate correction, ASB was genetically correlated with COVID-19 (r = 0.51; P = 1.54E-02) and 19 other traits. ASB and COVID-19 were both positively genetically correlated with having a noisy workplace, doing heavy manual labor, chronic obstructive pulmonary disease, and genitourinary diseases. ASB and COVID-19 were both inversely genetically correlated with average income, education years, healthspan, verbal reasoning, lifespan, cheese intake, and being breastfed as a baby. But keep in mind that r are not necessarily causal. And, if causal, their prevailing directions of effect (which causes which) are indiscernible from r alone. Moreover, the SNP-heritability ([Formula: see text]) estimates for two measures of COVID-19 were very small, restricting the overlap of genetic variance in absolute terms between ASB and COVID-19. Nonetheless, our findings suggest that those with antisocial tendencies possibly have a higher risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those without antisocial tendencies. This may have been especially true early in the pandemic before vaccines against SARS-CoV-2 were available and before the emergence of the highly transmissible Omicron variant.
关于违反规范和侵犯行为与 2019 年冠状病毒病（COVID-19）之间的遗传学关联，目前知之甚少。为了研究这一点，我们使用了全基因组关联研究和连锁不平衡评分回归的汇总统计数据，计算了反社会行为（ASB）、COVID-19 以及各种健康和行为特征的遗传相关性（r）矩阵。经过错误发现率校正后，ASB 与 COVID-19（r=0.51；P=1.54E-02）和其他 19 种特征存在遗传相关性。ASB 和 COVID-19 均与嘈杂的工作场所、繁重的体力劳动、慢性阻塞性肺疾病和泌尿生殖系统疾病呈正相关。ASB 和 COVID-19 均与平均收入、受教育年限、健康寿命、言语推理、寿命、奶酪摄入量和婴儿母乳喂养呈负相关。但请记住，r 不一定具有因果关系。而且，如果具有因果关系，则仅凭 r 无法确定它们的作用方向（哪个导致哪个）。此外，COVID-19 的两项衡量标准的 SNP 遗传度 ([Formula: see text]) 估计值非常小，从而限制了 ASB 和 COVID-19 之间遗传方差的绝对重叠。尽管如此，我们的研究结果表明，与没有反社会倾向的人相比，具有反社会倾向的人可能面临更高的感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的风险。在 COVID-19 大流行早期，在 SARS-CoV-2 疫苗可用且高传染性的奥密克戎变体出现之前，这种情况可能尤其如此。
