Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, Guangdong, People's Republic of China.
Aesthetic Plast Surg. 2022 Jun;46(3):1432-1438. doi: 10.1007/s00266-022-02865-z. Epub 2022 May 10.
The survival rate of fat transplants is variable and consequently multiple operations are often required to achieve satisfactory results. Fat cryopreservation technology is a good solution to this problem. At present, cryopreservation of fats needs to be added with cryopreservation agents, which brings unsafety and operational complexity to clinical applications. An efficient and safe strategy for fat cryopreservation must be developed.
A retrospective study was performed of all patients who underwent facial fat grafting and agreed to have their fat tissue cryopreserved from January 2018 to May 2021. Fat samples were physically processed to obtain SVF-gel, which was cryopreserved at - 20 °C for up to 3 months and injected after thawing. Images acquired by pre- and post-operative 3D scanning of the temporal region were compared to evaluate the retention rate of transplanted cryopreserved SVF-gel.
No patients experienced serious complications after receiving cryopreserved fat transplantation. The retention rate of cryopreserved SVF-gel was 46.3 ± 7.7% at 3 months and 43.1 ± 7.2% at 6 months after transplantation. The swelling duration was significantly shorter after cryopreserved SVF-gel transplantation (5.5 ± 0.8 days) than after fresh fat transplantation (7.5 ± 0.7 days) (p < .031).
Injection of cryopreserved SVF-gel achieves good retention rate for facial rejuvenation and has few side effects. Cryopreservation of SVF-gel is a safe and effective strategy for serial fat grafting for facial rejuvenation.
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脂肪移植的成活率存在差异，因此为了达到满意的效果，通常需要多次手术。脂肪冷冻保存技术是解决这一问题的一个很好的方法。目前，脂肪的冷冻保存需要加入冷冻保护剂，这给临床应用带来了不安全和操作复杂的问题。必须开发一种有效的、安全的脂肪冷冻保存策略。
对 2018 年 1 月至 2021 年 5 月期间所有行面部脂肪移植并同意冷冻保存脂肪组织的患者进行回顾性研究。对脂肪样本进行物理处理以获得 SVF-凝胶，将其在-20°C 下冷冻保存长达 3 个月，然后解冻后注射。通过术前和术后颞区的 3D 扫描获得图像，以评估移植冷冻保存的 SVF-凝胶的保留率。
接受冷冻保存脂肪移植的患者均未出现严重并发症。冷冻保存的 SVF-凝胶在移植后 3 个月的保留率为 46.3±7.7%，6 个月的保留率为 43.1±7.2%。冷冻保存的 SVF-凝胶移植后的肿胀持续时间（5.5±0.8 天）明显短于新鲜脂肪移植（7.5±0.7 天）（p＜0.031）。
注射冷冻保存的 SVF-凝胶对面部年轻化有很好的保留率，副作用较少。SVF-凝胶的冷冻保存是一种安全有效的策略，可用于面部年轻化的连续脂肪移植。
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