The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China, 310014.
BMC Surg. 2022 May 10;22(1):159. doi: 10.1186/s12893-022-01613-z.
This study aimed to investigate the clinical features, diagnostic criteria, treatment options, and prognosis of patients with gastric schwannoma (GS).
We collected the clinical data of all patients pathologically diagnosed with GS in Zhejiang Provincial People's Hospital from May 2012 to October 2021.
A total of 26 cases of GS were analyzed clinicopathologically, where the sizes of the tumor were found to be in the range of 1-6 cm (mean: 3.16 cm, median: 3.05 cm). A computed tomography (CT) scan analysis revealed that most masses were either moderately progressive or uniformly enhanced. According to ultrasound gastroscopy results, most of them were hypoechoic masses. There were 23 cases of surgery and three cases of endoscopic submucosal tumor dissection. Immunohistochemistry demonstrated that S100 was positive in 26 patients, immunomarker SOX10 was positive in five, whereas CD34, CD117, and SMA were negative in most patients. CK (Pan), Dog-1, and Desmin were also found negative. All 26 cases were followed up after the conclusion of the study where no evidence of recurrence or metastasis was observed.
GS is a unique form of peripheral schwannoma. The diagnosis of this type of tumor depends on the pathology and immunohistochemistry of the individual. The key to treating this type of tumor is endoscopy and surgery. Follow up and related literature review showed that GS was a benign tumor with little possibility of malignant transformation.
本研究旨在探讨胃 schwannoma（GS）患者的临床特征、诊断标准、治疗选择和预后。
我们收集了 2012 年 5 月至 2021 年 10 月期间在浙江省人民医院经病理诊断为 GS 的所有患者的临床资料。
共分析了 26 例 GS 患者的临床病理资料，肿瘤大小为 1-6cm（平均：3.16cm，中位数：3.05cm）。CT 扫描分析显示大多数肿块呈中度进展或均匀增强。根据超声胃镜结果，大多数为低回声肿块。23 例行手术治疗，3 例行内镜黏膜下肿瘤剥离术。免疫组织化学显示 26 例患者 S100 阳性，5 例 SOX10 阳性，而大多数患者 CD34、CD117 和 SMA 阴性，CK（Pan）、Dog-1 和 Desmin 也阴性。所有 26 例患者在研究结束后均进行了随访，未发现复发或转移的证据。
GS 是一种独特的外周 schwannoma 形式。这种肿瘤的诊断取决于个体的病理学和免疫组织化学。治疗这种类型肿瘤的关键是内镜和手术。随访和相关文献复习表明，GS 是一种良性肿瘤，恶性转化的可能性较小。
