Zou Long, Yang Ai-Ming
Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730, China.
Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Apr;44(2):294-298. doi: 10.3881/j.issn.1000-503X.12945.
Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer.This review addresses the major roles played by mucins and associated O-glycan structures in normal gastric epithelium.Further,we expound the alterations of expression patterns and glycan signatures of mucins at those pathological conditions.
黏蛋白是一类高度糖基化的蛋白质家族，主要存在于上皮细胞中。它们是上皮细胞的重要屏障，在细胞生理过程中发挥重要作用。在诸如感染、慢性萎缩性胃炎、肠化生、发育异常和胃癌等病理状态下，胃上皮中的黏蛋白会出现异常表达和糖基化。本综述阐述了黏蛋白及其相关O-聚糖结构在正常胃上皮中的主要作用。此外，我们还阐述了在这些病理状态下黏蛋白表达模式和聚糖特征的变化。
