Duarte Henrique O, Freitas Daniela, Gomes Catarina, Gomes Joana, Magalhães Ana, Reis Celso A
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Júlio Amaral de Carvalho, 45, Porto 4200-135, Portugal.
Institute of Molecular Pathology and Immunology of University of Porto, Ipatimup, Rua Júlio Amaral de Carvalho, 45, Porto 4200-135, Portugal.
Biomolecules. 2016 Jul 11;6(3):33. doi: 10.3390/biom6030033.
Mucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their glycan products constitute well-established molecular hallmarks of disease state. This review addresses the major role played by mucins and associated O-glycan structures in Helicobacter pylori adhesion to the gastric mucosa and the subsequent establishment of a chronic infection, with concomitant drastic alterations of the gastric epithelium glycophenotype. Furthermore, alterations of mucin expression pattern and glycan signatures occurring in preneoplastic lesions and in gastric carcinoma are also described, as well as their impact throughout the gastric carcinogenesis cascade and in cancer progression. Altogether, mucin-type O-glycosylation alterations may represent promising biomarkers with potential screening and prognostic applications, as well as predictors of cancer patients' response to therapy.
粘蛋白型O-糖基化在胃组织的多种生理和病理过程中起着关键作用。负责关键糖基化步骤的酶的修饰以及其聚糖产物随之而来的异常生物合成和表达构成了疾病状态公认的分子标志。本综述阐述了粘蛋白和相关O-聚糖结构在幽门螺杆菌粘附于胃黏膜以及随后建立慢性感染过程中所起的主要作用，同时伴随着胃上皮糖表型的剧烈改变。此外，还描述了癌前病变和胃癌中发生的粘蛋白表达模式和聚糖特征的改变，以及它们在整个胃癌发生级联反应和癌症进展中的影响。总之，粘蛋白型O-糖基化改变可能代表着具有潜在筛查和预后应用价值的有前景的生物标志物，以及癌症患者对治疗反应的预测指标。
