Department of Orthopedics, Deyang People's Hospital, Deyang, Sichuan, China.
Department of Cardiology, Deyang People's Hospital, Deyang, Sichuan, China.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221100806. doi: 10.1177/10760296221100806.
To analyze the relationship between monocyte count and preoperative deep venous thrombosis (DVT) in older patients with hip fracture.
Consecutive older patients with hip fracture undergoing surgery were included from January 2014 to December 2021. Monocyte count was measured on admission, and Doppler ultrasonography was performed for DVT screening prior to surgery. Univariate and multivariate logistic regression analyses were used to assess the association between monocyte count and DVT.
A total of 674 patients were finally included, and 128 patients (19.0%) were diagnosed with preoperative DVT. Patients with DVT exhibited a higher monocyte count than patients without DVT [0.55 (0.43-0.72) × 10/L versus 0.49 (0.38-0.63) × 10/L, = 0.007]. Multivariate logistic regression analysis showed that a high monocyte count (> 0.6 × 10/L) was independently associated with a higher risk of DVT (OR = 1.705, 95% : 1.121-2.593, = 0.013), and for every 0.1 × 10/L increase in monocyte count, the risk of DVT increased by 8.5% (OR = 1.085, 95% : 1.003-1.174, = 0.041). Other risk factors associated with DVT included intertrochanteric fracture (OR = 1.596, 95% : 1.022-2.492, = 0.040), and elevated fibrinogen level (OR = 1.236, 95% : 1.029-1.484, = 0.023).
A high monocyte count is associated with an increased risk of DVT in older patients with hip fracture. Future studies should evaluate the potential role of monocyte in the prevention and treatment of thrombosis.
分析老年髋部骨折患者单核细胞计数与术前深静脉血栓形成（DVT）的关系。
连续纳入 2014 年 1 月至 2021 年 12 月期间接受手术治疗的老年髋部骨折患者。入院时测量单核细胞计数，术前进行多普勒超声检查以筛查 DVT。采用单因素和多因素逻辑回归分析评估单核细胞计数与 DVT 之间的关系。
共纳入 674 例患者，其中 128 例（19.0%）术前诊断为 DVT。与无 DVT 的患者相比，DVT 患者的单核细胞计数更高[0.55（0.43-0.72）×10/L 比 0.49（0.38-0.63）×10/L， = 0.007]。多因素逻辑回归分析显示，高单核细胞计数（>0.6×10/L）与 DVT 风险增加独立相关（OR = 1.705，95%：1.121-2.593， = 0.013），单核细胞计数每增加 0.1×10/L，DVT 风险增加 8.5%（OR = 1.085，95%：1.003-1.174， = 0.041）。与 DVT 相关的其他危险因素包括转子间骨折（OR = 1.596，95%：1.022-2.492， = 0.040）和纤维蛋白原水平升高（OR = 1.236，95%：1.029-1.484， = 0.023）。
老年髋部骨折患者单核细胞计数升高与 DVT 风险增加相关。未来的研究应评估单核细胞在血栓预防和治疗中的潜在作用。
