在过量产生RecA蛋白的紫外线照射大肠杆菌中嘧啶二聚体切除的抑制作用。
Inhibition of pyrimidine dimer excision in ultraviolet-irradiated Escherichia coli overproducing RecA protein.
作者信息
Sedliaková M, Kleibl K, Masek F
出版信息
Mutat Res. 1987 May;191(1):13-6. doi: 10.1016/0165-7992(87)90163-1.
PMID:3553924
Abstract
Escherichia coli Br Hcr+ cells transformed with the recombinant multicopy plasmid pBR322 carrying recA gene contain increased amounts of RecA protein. When these cells were UV-irradiated, excision of pyrimidine dimers was reduced by about 50%. It is suggested that the damaged DNA strands may be coated with RecA protein which makes them insensitive to the action of the uvrABC excision nuclease.
摘要
用携带recA基因的重组多拷贝质粒pBR322转化的大肠杆菌Br Hcr⁺细胞含有增加量的RecA蛋白。当这些细胞受到紫外线照射时，嘧啶二聚体的切除减少了约50%。有人提出，受损的DNA链可能被RecA蛋白覆盖，这使得它们对uvrABC切除核酸酶的作用不敏感。
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引用本文的文献
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In UV-irradiated Escherichia coli PQ35 overproducing the RecA protein, expression of the sfiA gene and dimer excision are alleviated.在紫外线照射过的过量产生RecA蛋白的大肠杆菌PQ35中，sfiA基因的表达和二聚体切除得以缓解。
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