一种用于癌症光热治疗的金纳米颗粒二硫醇-聚乙二醇自组装的可行策略。

A feasible strategy for self-assembly of gold nanoparticles dithiol-PEG for photothermal therapy of cancers.

作者信息

Fu Yingjie, Feng Qishuai, Shen Yajing, Chen Mengwei, Xu Chang, Cheng Yu, Zhou Xiang

机构信息

The Institute for Advanced Studies, Wuhan University Wuhan 430072 China

College of Chemistry and Molecular Science, Wuhan University Wuhan 430072 China.

出版信息

RSC Adv. 2018 Feb 7;8(11):6120-6124. doi: 10.1039/c7ra12735a. eCollection 2018 Feb 2.

We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.