Newman M R, Russell S G, Benoit D S W
Department of Biomedical Engineering, University of Rochester Rochester NY 14627 USA
Center for Musculoskeletal Research, University of Rochester Medical Center Rochester NY 14642 USA.
RSC Adv. 2018 Aug 14;8(51):28891-28894. doi: 10.1039/c8ra05306e.
A systematic approach to the synthesis of organocatalyzed oligo(d,l-lactide) demonstrates that choice of initiator, catalytic ratio, and reaction time yields well-controlled oligomers. Ring-opening polymerization of d,l-lactide with the initiator α-methyl propargyl alcohol, a secondary alcohol, used in excess of 4-dimethylaminopyridine catalyst mitigates cyclicization, transesterification, and catalyst-initiated side reactions. This approach enables the design of uniform lactide oligomers for controlled release applications, such as delivery systems for drugs, prodrugs, and molecular sensors.
一种用于合成有机催化的聚（d，l-丙交酯）的系统方法表明，引发剂的选择、催化比例和反应时间能够产生可控的低聚物。使用过量4-二甲氨基吡啶催化剂，以仲醇α-甲基炔丙醇作为引发剂，进行d，l-丙交酯的开环聚合，可减轻环化、酯交换和催化剂引发的副反应。这种方法能够设计出用于控释应用的均匀丙交酯低聚物，如药物、前药和分子传感器的递送系统。
