Jiang Guangyou, Liu Min, Fang Dongmei, Tan Ping, Huang Min, Zhou Taiping, Jiang Zhenju, Xu Zhihong, Wang Zhouyu
Department of Chemistry, Xihua University Chengdu 610039 China
Chengdu Institute of Biology, Chinese Academy of Sciences Chengdu 610041 China.
RSC Adv. 2018 Feb 28;8(16):8961-8964. doi: 10.1039/c8ra00326b. eCollection 2018 Feb 23.
An ,-diisopropylethylamine promoted solvent-free Ramachary reductive coupling/alkylation (RRC/A) reaction for the synthesis of 2,2-disubstituted ethyl cyanoacetates has been developed. A series of 2,2-disubstituted ethyl cyanoacetates were synthesized in one pot by the RRC/A reaction of commercially available aldehydes, ethyl cyanacetates, alkyl halides and Hantzsch ester. A solvent free two step multicomponent reaction has also been developed for the preparation of 2,2-dialkylated malononitriles and 2,2-dialkylated 4-nitrophenyl acetonitriles. All the designed RRC/A products could be easily obtained with good yields by these methods.
已开发出一种由二异丙基乙胺促进的无溶剂拉马查里还原偶联/烷基化（RRC/A）反应，用于合成2,2-二取代的氰基乙酸乙酯。通过市售醛、氰基乙酸乙酯、卤代烃和汉茨希酯的RRC/A反应，一锅法合成了一系列2,2-二取代的氰基乙酸乙酯。还开发了一种用于制备2,2-二烷基丙二腈和2,2-二烷基-4-硝基苯乙腈的无溶剂两步多组分反应。通过这些方法可以轻松获得所有设计的RRC/A产物，且产率良好。
