Kootstra G, van Hooff J P, Jörning P J, Leunissen K M, van der Linden C J, Beukers E, Buurman W A
Neth J Surg. 1987 Feb;39(1):32-6.
A successful pancreatic transplant together with a kidney graft makes type-I diabetic patients with end-stage diabetic nephropathy independent from insulin and dialysis. Several surgical techniques for the pancreatic graft are employed. Major problems are thrombosis of the graft and the handling of the exocrine secretion of the pancreas. A transplant model is presented that reduces the risk of thrombosis by including the spleen in the graft. The exocrine secretion is handled by transplanting a segment of duodenum with the graft and by connecting this segment to the recipient's bladder. Experience has been gained in four patients. All are insulin-independent. Severe complications have not been observed, which makes this model suitable for further assessment of the effect of pancreatic transplantation on the course of type-I diabetic patients.
成功的胰腺移植联合肾脏移植可使患有终末期糖尿病肾病的I型糖尿病患者摆脱胰岛素和透析。目前采用了几种胰腺移植的手术技术。主要问题是移植物血栓形成以及胰腺外分泌的处理。本文介绍了一种移植模型，该模型通过在移植物中包含脾脏来降低血栓形成的风险。外分泌通过将一段十二指肠与移植物一起移植并将该段连接到受体的膀胱来处理。已对四名患者进行了试验。所有患者均不再依赖胰岛素。未观察到严重并发症，这使得该模型适合进一步评估胰腺移植对I型糖尿病患者病程的影响。
