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来自支化共聚物的pH响应性聚合物囊泡。

pH-responsive polymeric vesicles from branched copolymers.

作者信息

Zhou Jinglun, Li Linlin, Wang Weishan, Zhao Yang, Feng Shengyu

机构信息

Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University Jinan 250100 China

Eco-Benign Plastics Technology Company Limited Jinan 250101 China.

出版信息

RSC Adv. 2019 Dec 11;9(70):41031-41037. doi: 10.1039/c9ra08703f. eCollection 2019 Dec 9.

DOI:10.1039/c9ra08703f
PMID:35540065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9076388/
Abstract

A new type of branched copolymer, poly(l-lactide)--poly(l-glutamic acid) (PLLA-PLGA), based on polypeptide PLGA is synthesized by the ring-opening polymerization (ROP) of -carboxyanhydride of γ-benzyl-l-glutamate (BLG-NCA) with amino-terminated PLLA-NH and subsequent deprotection. The branched copolymer is characterized by H NMR, FTIR and GPC measurements. The self-assembly of the copolymers in aqueous media has been systematically discussed. A pyrene probe has been used to demonstrate the aggregated formation of PLLA-PLGA in solution by measuring the critical micelle concentration (cmc). The morphology and size of the micelles have further been studied by transmission electron microscopy (TEM), dynamic light scattering (DLS) and field emission scanning electron microscopy (ESEM). We demonstrated that the Rh of the vesicle is depending on solution pH and salt concentration. The vesicles show good stability with remained shapes and sizes during the lyophilizing process. These vesicles have great potential in the application of drug delivery.

摘要

一种基于多肽聚（L-谷氨酸）的新型支化共聚物聚（L-丙交酯）-聚（L-谷氨酸）（PLLA-PLGA），通过γ-苄基-L-谷氨酸（BLG-NCA）的羧基酸酐与氨基封端的PLLA-NH进行开环聚合（ROP）并随后脱保护来合成。通过核磁共振氢谱（¹H NMR）、傅里叶变换红外光谱（FTIR）和凝胶渗透色谱（GPC）测量对该支化共聚物进行表征。系统地讨论了共聚物在水性介质中的自组装。使用芘探针通过测量临界胶束浓度（cmc）来证明PLLA-PLGA在溶液中的聚集形成。通过透射电子显微镜（TEM）、动态光散射（DLS）和场发射扫描电子显微镜（ESEM）进一步研究了胶束的形态和尺寸。我们证明了囊泡的流体力学半径（Rh）取决于溶液的pH值和盐浓度。这些囊泡在冻干过程中表现出良好的稳定性，形状和尺寸保持不变。这些囊泡在药物递送应用中具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/865dd1eea879/c9ra08703f-f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/a87da8b2083b/c9ra08703f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/19b896b7bb42/c9ra08703f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/73b44b9162c2/c9ra08703f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/865dd1eea879/c9ra08703f-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/138ac1d2cd1a/c9ra08703f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/f0eeaa62a852/c9ra08703f-f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/778c23adacf3/c9ra08703f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/3850d325d795/c9ra08703f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/6165a8e6db85/c9ra08703f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/eb34dc45b3d7/c9ra08703f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/a87da8b2083b/c9ra08703f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/19b896b7bb42/c9ra08703f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/73b44b9162c2/c9ra08703f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a63/9076388/865dd1eea879/c9ra08703f-f10.jpg

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