Hall M E, Granholm A C, Stevens J O, Hoffer B J
Neurosci Lett. 1987 Mar 20;75(1):89-94. doi: 10.1016/0304-3940(87)90081-4.
Heart atria and cortex cerebri from fetal rabbits (E14 and E18, respectively) were grafted into the anterior eye chamber of anesthetized athymic nude rats and allowed to mature for 2-11 weeks. All grafts received a rich vascular supply from the host iris. Atrial transplants survived well but showed no significant growth while cortex grafts increased in size an average of 320%. Spontaneous action potentials were recorded from cellular elements in both tissues and, in the case of the atria, were accompanied by observable contractions. Functional cholinergic innervation from the autonomic ground plexus of the iris was elicited in both types of grafts by phasic retinal illumination. No evidence of immunologic rejection was found by histological analysis. Taken together, these data suggest that athymic rats may provide an appropriate host environment to study transplants of the central nervous and peripheral tissue from immunologically otherwise incompatible mammalian species.
分别取自胎兔（E14和E18）的心房和大脑皮层被移植到麻醉的无胸腺裸鼠的前房，并使其成熟2至11周。所有移植物都从宿主虹膜获得了丰富的血管供应。心房移植存活良好，但没有显著生长，而皮层移植物的大小平均增加了320%。在两种组织的细胞成分中都记录到了自发动作电位，在心房的情况下，还伴有可观察到的收缩。通过阶段性视网膜照明，在两种类型的移植物中都引发了来自虹膜自主基层神经丛的功能性胆碱能神经支配。组织学分析未发现免疫排斥的证据。综上所述，这些数据表明，无胸腺大鼠可能为研究来自免疫上不兼容的哺乳动物物种的中枢神经和外周组织的移植提供合适的宿主环境。
