过氧铌抑制白血病细胞生长。

Pereira-Maia Elene C, Souza Ivina P, Nunes Kelen J R C, Castro Alexandre A, Ramalho Teodorico C, Steffler Fernando, Duarte Helio A, Pacheli Ana, Chagas Poliana, Oliveira Luiz C A

Universidade Federal de Minas Gerais, Department of Chemistry Av. Antonio Carlos 6627 Belo Horizonte MG 31270-901 Brazil

Universidade Federal de Lavras, Department of Chemistry Lavras MG 37200-000 Brazil.

RSC Adv. 2018 Mar 14;8(19):10310-10313. doi: 10.1039/c8ra00898a. eCollection 2018 Mar 13.

A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.

一类新型的聚氧铌酸盐配合物已被合成并表征为一种用于光动力疗法的新型抗癌剂。该配合物在黑暗中以30μM的IC值抑制慢性粒细胞白血病细胞的生长。然而，在暴露于光（365nm）后，细胞毒性活性增加了五倍。根据我们的实验和理论数据，光辐射激活该配合物，形成能够与DNA相互作用的自由基物种。