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用于骨组织工程的碳纳米管增强聚乙烯醇/双相磷酸钙支架

Carbon nanotube reinforced polyvinyl alcohol/biphasic calcium phosphate scaffold for bone tissue engineering.

作者信息

Lan Weiwei, Zhang Xiumei, Xu Mengjie, Zhao Liqin, Huang Di, Wei Xiaochun, Chen Weiyi

机构信息

Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology Taiyuan 030024 PR China

Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology Taiyuan 030024 PR China.

出版信息

RSC Adv. 2019 Nov 28;9(67):38998-39010. doi: 10.1039/c9ra08569f. eCollection 2019 Nov 27.

DOI:10.1039/c9ra08569f
PMID:35540653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075967/
Abstract

In this paper, a well-developed porous carbon nanotube (CNT) reinforced polyvinyl alcohol/biphasic calcium phosphate (PVA/BCP) scaffold was fabricated by a freeze-thawing and freeze-drying method. The microstructure, mechanical properties and the composition of the scaffolds were characterized by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results illustrate that after the incorporation of CNTs, the compressive strength of the hydrogels (moisture state) reached 81 ± 6 kPa, presenting a significantly higher value than that of pure PVA/BCP hydrogels (48 ± 2 kPa). Meanwhile, CNT reinforced PVA/BCP scaffolds exhibited a porous structure and high interconnectivity (80 ± 0.6%). The degradation analysis indicated that the degradation ratio of scaffolds can be varied by changing the concentrations of BCP powders and CNTs. Cell culture results show that PVA/BCP/CNT porous scaffolds have no negative effects on the survival and proliferation of cells. These results strongly show that the composite scaffolds may possess a potential application in the field of bone tissue engineering and regeneration.

摘要

在本文中，通过冻融和冷冻干燥法制备了一种结构完善的多孔碳纳米管（CNT）增强聚乙烯醇/双相磷酸钙（PVA/BCP）支架。通过场发射扫描电子显微镜（FE-SEM）、X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）对支架的微观结构、力学性能和组成进行了表征。结果表明，加入碳纳米管后，水凝胶（湿润状态）的抗压强度达到81±6 kPa，明显高于纯PVA/BCP水凝胶（48±2 kPa）。同时，碳纳米管增强的PVA/BCP支架呈现出多孔结构和高连通性（80±0.6%）。降解分析表明，通过改变BCP粉末和碳纳米管的浓度可以改变支架的降解率。细胞培养结果表明，PVA/BCP/CNT多孔支架对细胞的存活和增殖没有负面影响。这些结果有力地表明，复合支架在骨组织工程和再生领域可能具有潜在的应用价值。

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