Stallworth Jeannette Y, Horton Jonathan C
University of California San Francisco, Department of Ophthalmology, San Francisco, CA, 94158 USA.
Am J Ophthalmol Case Rep. 2022 Apr 30;26:101559. doi: 10.1016/j.ajoc.2022.101559. eCollection 2022 Jun.
To describe a case of severe, bilateral periorbital edema after hematopoietic stem cell transplantation.
A three-year old girl with metastatic neuroblastoma underwent the second of two tandem autologous peripheral blood stem cell transplants, complicated by engraftment syndrome. On post-engraftment day 11, she developed acute onset of severe periorbital edema. She was soon thereafter diagnosed with transplant-associated thrombotic microangiopathy with significant volume overload requiring treatment with eculizumab and etanercept. Periorbital edema resolved after four days with concurrent treatment of her underlying condition.
We report an ocular manifestation related to complications of hematopoietic stem cell transplantation. This highlights a non-infectious etiology of eyelid swelling in the post-transplant, immunocompromised population.
描述一例造血干细胞移植后严重双侧眶周水肿的病例。
一名患有转移性神经母细胞瘤的三岁女孩接受了两次串联自体外周血干细胞移植中的第二次，并发植入综合征。在植入后第11天，她突然出现严重眶周水肿。此后不久，她被诊断为移植相关血栓性微血管病，伴有明显容量超负荷，需要使用依库珠单抗和依那西普治疗。眶周水肿在四天后随着基础疾病的同时治疗而消退。
我们报告了一种与造血干细胞移植并发症相关的眼部表现。这突出了移植后免疫功能低下人群眼睑肿胀的非感染性病因。
