Pessagno Federica, Hasanah Aliya Nur, Manesiotis Panagiotis
School of Chemistry and Chemical Engineering, Queen's University Belfast David Keir Building, Stranmillis Road BT9 5AG Belfast Northern Ireland UK
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran Jl Raya Bandung Sumedang KM 21,5 Jatinangor Indonesia.
RSC Adv. 2018 Apr 17;8(26):14212-14220. doi: 10.1039/c8ra01135d.
A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >10 M between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration.
提出了一种基于可聚合离子对识别磺酰脲类药物的新方法。测得模型目标药物格列本脲与甲基丙烯酸4-乙烯基苄基三甲基铵之间的溶液缔合常数>10 M，并验证了1:1配合物的形成。随后制备的化学计量印迹聚合物对格列本脲表现出极高的亲和力和结合能力，这归因于离子对单体对药物中性和去质子化形式的协同结合。这些聚合物应用于从血清样品中选择性萃取格列本脲，回收率高达98%，并表现出优异的长期稳定性，无需定期进行吸附剂再生。
