Galletti P, Martelli G, Prandini G, Colucci C, Giacomini D
Department of Chemistry "G. Ciamician" University of Bologna Bologna 40126 Italy
RSC Adv. 2018 Mar 7;8(18):9723-9730. doi: 10.1039/c8ra01365a. eCollection 2018 Mar 5.
A new metal-free protocol for promoting oxidation of amines in aqueous-organic medium was developed. NaIO and TEMPO as the catalyst emerged as the most efficient and selective system for oxidation of differently substituted benzyl amines to the corresponding benzaldehydes without overoxidation. Unsymmetrical secondary amines underwent selective oxidation only at the benzylic position thus realising an oxidative deprotection of a benzylic group with an easy amine recovery.
开发了一种用于促进水-有机介质中胺氧化的新型无金属方案。NaIO和TEMPO作为催化剂，是将不同取代的苄胺氧化为相应的苯甲醛而不会过度氧化的最有效和选择性最高的体系。不对称仲胺仅在苄基位置发生选择性氧化，从而实现苄基的氧化脱保护，并能轻松回收胺。
