无金属高价碘/ TEMPO介导的胺氧化反应及其反应途径的机理探究

Metal-free hypervalent iodine/TEMPO mediated oxidation of amines and mechanistic insight into the reaction pathways.

作者信息

Bansode Ajay H, Suryavanshi Gurunath

机构信息

Chemical Engineering & Process Development Division, CSIR-National Chemical Laboratory Dr Homi Bhabha Road Pune-411008 India

Academy of Scientific and Innovative Research (AcSIR) New Delhi 110 025 India.

出版信息

RSC Adv. 2018 Sep 14;8(56):32055-32062. doi: 10.1039/c8ra07451h. eCollection 2018 Sep 12.

A highly efficient metal free approach for the oxidation of primary and secondary amines to their corresponding aldehydes and ketones using PhI(OAc) in combination with a catalytic amount of TEMPO as an oxidizing agent is described. This protocol is rapid and provides diverse products under milder reaction conditions in excellent yields. In addition, the mechanistic study is well demonstrated by spectroscopic methods.