新型笼形荧光素衍生物可延长生物发光成像时间，并且……（原文此处不完整）
Novel caged luciferin derivatives can prolong bioluminescence imaging and .
作者信息
Zhang Chaochao, Yuan Mingliang, Han Guangxi, Gao Yuqi, Tang Chunchao, Li Xiang, Du Lupei, Li Minyong
机构信息
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University Jinan Shandong 250012 China
State Key Laboratory of Microbial Technology, Shandong University Jinan Shandong 250100 China.
出版信息
RSC Adv. 2018 May 30;8(35):19596-19599. doi: 10.1039/c8ra02312c. eCollection 2018 May 25.
Based on -cyclobutylaminoluciferin (cybLuc), a set of high and efficient caged bioluminescent derivatives (Clucs) as firefly luciferase pro-substrates has been developed herein. After careful examination, these molecules exhibited low cytotoxicity and prolonged bioluminescence imaging up to 6 h and . Importantly, these caged luciferin derivatives have the potential to serve as long-term tracking tools to explore some biological process by using bioluminescent imaging.
基于环丁基氨基荧光素（cybLuc），本文开发了一组高效的笼蔽生物发光衍生物（Clucs）作为萤火虫荧光素酶前体底物。经过仔细研究，这些分子表现出低细胞毒性，生物发光成像延长至6小时及以上。重要的是，这些笼蔽荧光素衍生物有潜力作为长期追踪工具，通过生物发光成像来探索一些生物学过程。
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