铜催化硫醇与5-芳基戊-2,4-二烯酸乙酯的C-S直接交叉偶联反应。
Copper-catalyzed C-S direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester.
作者信息
Cai Rongrong, Zhou Zhuoda, Chai Qianqian, Zhu Yueer, Xu Runsheng
机构信息
Department of Biology and Environment, Jiyang College of Zhejiang A & F University Shaoxing 311800 Zhejiang China
出版信息
RSC Adv. 2018 Jul 27;8(47):26828-26836. doi: 10.1039/c8ra05311a. eCollection 2018 Jul 24.
A selective copper (Cu)-catalyzed C-S bond direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester was developed. Notably, various biologically active 5-phenyl-3-phenylsulfanylpenta-2,4-dienoic acid ethyl ester derivatives were efficiently synthesized under moderate conditions. Finally, a plausible Cu(i)/Cu(iii) reaction mechanism was proposed.
开发了一种选择性铜（Cu）催化的硫醇与5-芳基戊-2,4-二烯酸乙酯的C-S键直接交叉偶联反应。值得注意的是，在温和条件下高效合成了各种具有生物活性的5-苯基-3-苯基硫烷基戊-2,4-二烯酸乙酯衍生物。最后，提出了一种合理的Cu(i)/Cu(iii)反应机理。
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