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N,N-二甲基甲酰胺参与合成硒代苯基二甲基氨基甲酸硒酯衍生物的多米诺反应

,-Dimethylformamide's Participation in Domino Reactions for the Synthesis of Se-Phenyl Dimethylcarbamoselenoate Derivatives.

作者信息

Xu Runsheng, Hu Shenhuanran, Wu Luhui, Ning Yifan, Xu Jin

机构信息

College of Life and Health, Huzhou College, Huzhou 211300, China.

出版信息

Molecules. 2025 Feb 6;30(3):747. doi: 10.3390/molecules30030747.

DOI:10.3390/molecules30030747
PMID:39942849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11820005/
Abstract

,-dimethylformamide's (DMF) participation in domino reactions has been developed. Starting from substituted halogenobenzenes and selenium powder, versatile biologically active Se-phenyl dimethylcarbamoselenoate derivatives were efficiently synthesized under mild reaction conditions. The reaction mechanism was studied using control experiments. These protocols involve a wider substrate scope and provide an economical approach toward C-selenium bond formation.

摘要

二甲基甲酰胺（DMF）参与的多米诺反应已得到发展。从取代卤代苯和硒粉出发，在温和的反应条件下高效合成了多种具有生物活性的硒代苯基二甲基氨基甲酸硒酯衍生物。通过对照实验研究了反应机理。这些方法具有更广泛的底物范围，并为碳-硒键的形成提供了一种经济的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/0be098d854b1/molecules-30-00747-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/29b2c0cf9887/molecules-30-00747-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/c87f5f49c340/molecules-30-00747-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/58c6f9154ebe/molecules-30-00747-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/0be098d854b1/molecules-30-00747-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/29b2c0cf9887/molecules-30-00747-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/c87f5f49c340/molecules-30-00747-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/58c6f9154ebe/molecules-30-00747-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9ed/11820005/0be098d854b1/molecules-30-00747-sch004.jpg

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本文引用的文献

1
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J Org Chem. 2024 Dec 6;89(23):16977-16989. doi: 10.1021/acs.joc.4c02409. Epub 2024 Nov 21.
2
Rongalite/iodine-mediated C(sp)-H bond oximation and thiomethylation reaction of methyl ketones using copper nitrate as the [NO] reagent: synthesis of thiohydroximic acids.以硝酸铜作为[NO]试剂，用雕白粉/碘介导的甲基酮的C(sp)-H键肟化和硫甲基化反应：硫代肟酸的合成
Org Biomol Chem. 2024 Sep 25;22(37):7623-7627. doi: 10.1039/d4ob01217h.
3
Total Syntheses of Phorbol and 11 Tigliane Diterpenoids and Their Evaluation as HIV Latency-Reversing Agents.
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J Am Chem Soc. 2024 Mar 27;146(12):8746-8756. doi: 10.1021/jacs.4c01589. Epub 2024 Mar 14.
4
Rongalite as C1 Synthon in the Synthesis of Divergent Pyridines and Quinolines.Rongalite 作为 C1 前体在合成不同的吡啶和喹啉中的应用。
J Org Chem. 2023 Jun 2;88(11):7188-7198. doi: 10.1021/acs.joc.3c00428. Epub 2023 May 12.
5
Fluorescent Nanoparticles for Super-Resolution Imaging.用于超分辨率成像的荧光纳米颗粒。
Chem Rev. 2022 Aug 10;122(15):12495-12543. doi: 10.1021/acs.chemrev.2c00050. Epub 2022 Jun 27.
6
Copper-photocatalyzed ATRA reactions: concepts, applications, and opportunities.铜光催化 ATRA 反应：概念、应用与机遇。
Chem Soc Rev. 2022 Jul 4;51(13):5287-5299. doi: 10.1039/d2cs00303a.
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8
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9
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Acc Chem Res. 2021 Aug 3;54(15):3071-3082. doi: 10.1021/acs.accounts.1c00277. Epub 2021 Jul 15.