通过双功能有机催化剂的氧杂-迈克尔-迈克尔串联反应对高度取代色满进行对映选择性合成。
Enantioselective Synthesis of Highly Substituted Chromans via the Oxa-Michael-Michael Cascade Reaction with a Bifunctional Organocatalyst.
作者信息
Saha Prasenjit, Biswas Arnab, Molleti Nagaraju, Singh Vinod K
机构信息
Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal 462066, India.
Department of Chemistry, Indian Institute of Technology , Kanpur 208016, India.
出版信息
J Org Chem. 2015 Nov 6;80(21):11115-22. doi: 10.1021/acs.joc.5b01751. Epub 2015 Oct 26.
A highly enantioselective synthesis of chiral chroman derivatives via an oxa-Michael-Michael cascade reaction has been developed using a bifunctional thiourea organocatalyst. The products were obtained with excellent enantioselectivities (up to >99%), good yields (up to 95%), and diastereoselectivities (up to 5:1).
利用双功能硫脲有机催化剂，通过氧杂 - 迈克尔 - 迈克尔串联反应开发了一种手性苯并二氢吡喃衍生物的高度对映选择性合成方法。产物具有优异的对映选择性（高达>99%）、良好的产率（高达95%）和非对映选择性（高达5:1）。
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