Pananon Paweena, Sriprachuabwong Chakrit, Wisitsoraat Anurat, Chuysinuan Piyachat, Tuantranont Adisorn, Saparpakorn Patchareenart, Dechtrirat Decha
Department of Materials Science, Faculty of Science, Kasetsart University Bangkok Thailand
National Electronics and Computer Technology Center (NECTEC), National Science and Technology Development Agency (NSTDA) Pathumthani Thailand.
RSC Adv. 2018 Apr 3;8(23):12724-12732. doi: 10.1039/c8ra01564c.
A facile one-pot and green method was developed to prepare a nanocomposite of gold nanoparticle (AuNP), graphene (GP) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). Graphene was first electro-exfoliated in a polystyrene sulfonate solution, followed by a one-step simultaneous formation of gold nanoparticle and PEDOT. The as-synthesized aqueous dispersion of AuNP-GP-PEDOT:PSS was thereafter used to modify the glassy carbon electrode (GCE). For the first time, the quaternary composite between AuNP, GP, PEDOT and PSS was used for selective determination of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid (AA). In comparison to a bare GCE, the nanocomposite electrode shows considerably higher electrocatalytic activities toward the oxidation of DA and UA due to a synergistic effect between AuNP, GP, PEDOT and PSS. Using differential pulse voltammetry (DPV), selective determination of DA and UA in the presence of AA could be achieved with a peak potential separation of 110 mV between DA and UA. The sensor exhibits wide linear responses for DA and UA in the ranges of 1 nM to 300 μM and 10 μM to 1 mM with detection limits (S/N = 3) of 100 pM and 10 μM, respectively. Furthermore, the proposed sensor was also successfully used to determine DA in a real pharmaceutical injection sample as well as DA and UA in human serum with satisfactory recovery results.
开发了一种简便的一锅法绿色方法来制备金纳米颗粒（AuNP）、石墨烯（GP）和聚（3,4 - 乙烯二氧噻吩）聚苯乙烯磺酸盐（PEDOT:PSS）的纳米复合材料。首先在聚苯乙烯磺酸盐溶液中对石墨烯进行电剥离，然后一步同时形成金纳米颗粒和PEDOT。此后，将合成的AuNP - GP - PEDOT:PSS水分散体用于修饰玻碳电极（GCE）。首次将AuNP、GP、PEDOT和PSS之间的四元复合材料用于在抗坏血酸（AA）存在下选择性测定多巴胺（DA）和尿酸（UA）。与裸GCE相比，由于AuNP、GP、PEDOT和PSS之间的协同效应，纳米复合电极对DA和UA的氧化表现出显著更高的电催化活性。使用差分脉冲伏安法（DPV），在AA存在下可以实现对DA和UA的选择性测定，DA和UA之间的峰电位分离为110 mV。该传感器对DA和UA在1 nM至300 μM和10 μM至1 mM范围内具有宽线性响应，检测限（S/N = 3）分别为100 pM和10 μM。此外，所提出的传感器还成功用于测定实际药物注射样品中的DA以及人血清中的DA和UA，回收率结果令人满意。
