• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

以颌骨棕色瘤为表现的慢性肾脏病

Chronic Kidney Disease Presenting With Brown Tumors in the Mandible.

作者信息

Singh Sumedha, Padhy Santosh K, Mohapatra Satya S, Panda Adya, Shahi Pratyush

机构信息

Radiology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

Radiodiagnosis, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

出版信息

Cureus. 2022 Apr 9;14(4):e23985. doi: 10.7759/cureus.23985. eCollection 2022 Apr.

DOI:10.7759/cureus.23985
PMID:35541298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9084424/
Abstract

A 45-year-old man with stage 4 chronic kidney disease (CKD) on controlled dialysis presented with right-sided painful jaw swelling and protruding into the oral cavity for one year. Examination revealed a 3 x 2.5-cm hard, fixed, and tender swelling of the right mandible. Imaging showed expansile radiolucent lesions in bilateral retromolar regions of the mandible, local destruction of the basal bone, and diffuse osteopenia of the skull. Laboratory investigations revealed elevated parathyroid hormone (PTH), elevated serum calcium, normal serum phosphorous, and elevated alkaline phosphatase (ALP). A provisional diagnosis of tertiary hyperparathyroidism (HPT) causing brown tumors was made, which was confirmed on histopathology. Surgical removal of the lesion and subtotal parathyroidectomy were done followed by cinacalcet and controlled dialysis. This case report highlights the possibility of encountering multiple focal brown tumors in a patient and the importance of their differentiation from malignancy.

摘要

一名45岁的4期慢性肾脏病（CKD）男性患者，接受可控透析治疗，出现右侧颌部疼痛性肿胀并突入口腔一年。检查发现右侧下颌骨有一个3×2.5厘米的坚硬、固定且压痛的肿胀。影像学检查显示双侧下颌磨牙后区有膨胀性透光性病变、基底骨局部破坏以及颅骨弥漫性骨质减少。实验室检查显示甲状旁腺激素（PTH）升高、血清钙升高、血清磷正常以及碱性磷酸酶（ALP）升高。初步诊断为导致棕色瘤的三发性甲状旁腺功能亢进（HPT），组织病理学检查证实了这一诊断。对病变进行了手术切除并进行了甲状旁腺次全切除术，随后使用西那卡塞并进行可控透析。本病例报告强调了在患者中遇到多个局灶性棕色瘤的可能性以及将其与恶性肿瘤区分开来的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/b8b6fbf32e9e/cureus-0014-00000023985-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/f17a1d0cdae0/cureus-0014-00000023985-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/dcf2952eba37/cureus-0014-00000023985-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/93be4dac6ff3/cureus-0014-00000023985-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/b8b6fbf32e9e/cureus-0014-00000023985-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/f17a1d0cdae0/cureus-0014-00000023985-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/dcf2952eba37/cureus-0014-00000023985-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/93be4dac6ff3/cureus-0014-00000023985-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20a5/9084424/b8b6fbf32e9e/cureus-0014-00000023985-i04.jpg

相似文献

1
Chronic Kidney Disease Presenting With Brown Tumors in the Mandible.以颌骨棕色瘤为表现的慢性肾脏病
Cureus. 2022 Apr 9;14(4):e23985. doi: 10.7759/cureus.23985. eCollection 2022 Apr.
2
Brown Tumour in the Mandible and Skull Osteosclerosis Associated with Primary Hyperparathyroidism - A Case Report.下颌骨棕色瘤与颅骨骨硬化症伴原发性甲状旁腺功能亢进——病例报告
Open Access Maced J Med Sci. 2018 Feb 1;6(2):406-409. doi: 10.3889/oamjms.2018.086. eCollection 2018 Feb 15.
3
Maxillofacial brown tumors in secondary hyperparathyroidism: A case report and literature review.继发性甲状旁腺功能亢进中的颌面部棕色瘤：一例报告及文献复习
J Res Med Sci. 2014 Nov;19(11):1099-102.
4
Primary Hyperparathyroidism With Brown Tumor of the Mandible Misdiagnosed as a Giant Cell Tumor: A Case Report.原发性甲状旁腺功能亢进伴下颌骨棕色瘤误诊为巨细胞瘤：病例报告
Cureus. 2024 Mar 14;16(3):e56153. doi: 10.7759/cureus.56153. eCollection 2024 Mar.
5
Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report.原发性甲状旁腺功能亢进症的溶骨性病变（棕色瘤）被误诊为尺骨和桡骨远端多灶性巨细胞瘤：一例报告
J Med Case Rep. 2018 Jun 25;12(1):176. doi: 10.1186/s13256-018-1723-y.
6
Brown Tumor With Spine Involvement at Multiple Levels in a Hemodialysis Patient.一名血液透析患者出现多节段脊柱受累的棕色瘤。
Cureus. 2021 Aug 8;13(8):e17000. doi: 10.7759/cureus.17000. eCollection 2021 Aug.
7
Brown tumor of the thoracic spine presenting with paraplegia in a patient with peritoneal dialysis.腹膜透析患者胸椎棕色瘤伴截瘫
CEN Case Rep. 2019 Nov;8(4):227-232. doi: 10.1007/s13730-019-00398-0. Epub 2019 May 14.
8
Brown tumor complicating end-stage kidney disease.棕色瘤并发终末期肾病。
Clin Nephrol Case Stud. 2020 Oct 12;8:72-79. doi: 10.5414/CNCS110195. eCollection 2020.
9
Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature.与原发性或继发性甲状旁腺功能亢进相关的颌骨棕色瘤。一项临床研究及文献综述。
Am J Otolaryngol. 2006 Jul-Aug;27(4):281-6. doi: 10.1016/j.amjoto.2005.11.004.
10
Orbital involvement in craniofacial brown tumors.颅面棕色瘤的眼眶累及。
Ophthalmic Plast Reconstr Surg. 2010 Mar-Apr;26(2):106-11. doi: 10.1097/IOP.0b013e3181b8e3ec.

引用本文的文献

1
A presentation of brown tumor in a patient with parathyroid adenoma and end-stage renal disease: A case report.甲状旁腺腺瘤合并终末期肾病患者棕色瘤的病例报告
Medicine (Baltimore). 2025 Sep 5;104(36):e44342. doi: 10.1097/MD.0000000000044342.
2
Brown Tumour in Chronic Kidney Disease: Revisiting an Old Disease with a New Perspective.慢性肾脏病中的棕色瘤：以新视角重新审视一种旧疾病
Cancers (Basel). 2023 Aug 15;15(16):4107. doi: 10.3390/cancers15164107.

本文引用的文献

1
Brown tumor of mandible in association with primary hyperparathyroidism: a case report.下颌骨棕色瘤伴原发性甲状旁腺功能亢进症：病例报告
J Int Oral Health. 2015 Feb;7(2):50-2.
2
Maxillofacial brown tumors in secondary hyperparathyroidism: A case report and literature review.继发性甲状旁腺功能亢进中的颌面部棕色瘤：一例报告及文献复习
J Res Med Sci. 2014 Nov;19(11):1099-102.
3
Primary hyperparathyroidism with rare presentation as multiple brown tumours.以多发性棕色瘤为罕见表现的原发性甲状旁腺功能亢进症。
Clin Pract. 2012 Apr 30;2(2):e48. doi: 10.4081/cp.2012.e48. eCollection 2012 Mar 30.
4
Brown tumor of the mandible associated with secondary hyperparathyroidism: a case report and review of the literature.下颌骨棕色瘤伴继发性甲状旁腺功能亢进：一例报告并文献复习
Gen Dent. 2006 Sep-Oct;54(5):341-3.
5
Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature.与原发性或继发性甲状旁腺功能亢进相关的颌骨棕色瘤。一项临床研究及文献综述。
Am J Otolaryngol. 2006 Jul-Aug;27(4):281-6. doi: 10.1016/j.amjoto.2005.11.004.
6
Oral and dental aspects of chronic renal failure.慢性肾衰竭的口腔和牙齿问题
J Dent Res. 2005 Mar;84(3):199-208. doi: 10.1177/154405910508400301.
7
Management changes in primary hyperparathyroidism.原发性甲状旁腺功能亢进症的管理变化
JAMA. 2000;284(8):934-6. doi: 10.1001/jama.284.8.934.
8
Musculoskeletal manifestations of chronic renal insufficiency.慢性肾功能不全的肌肉骨骼表现。
Radiographics. 1993 Mar;13(2):357-79. doi: 10.1148/radiographics.13.2.8460225.