Brook I
Pediatr Infect Dis J. 1987 Mar;6(3):332-5. doi: 10.1097/00006454-198703000-00049.
Studies evaluating the in vitro and in vivo synergistic potential of combined antimicrobial agents against anaerobic bacteria are reviewed. Most studies evaluated therapy against Bacteroides sp. (mostly Bacteroides fragilis group). The combinations found to be most effective against B. fragilis were between metronidazole and clindamycin, spiramycin or gentamicin and between clindamycin and aminoglycosides. Against Bacteroides melaninogenicus the effective combinations were penicillin or clindamycin plus gentamicin and metronidazole and spiramycin or gentamicin. Occasional synergy was observed against Clostridium sp. and anaerobic cocci with clindamycin and gentamicin. Synergistic combinations have the potential of clinical use in serious anaerobic infections.
本文综述了评估联合抗菌药物对厌氧菌的体外和体内协同潜力的研究。大多数研究评估了针对拟杆菌属（主要是脆弱拟杆菌群）的治疗。发现对脆弱拟杆菌最有效的联合用药是甲硝唑与克林霉素、螺旋霉素或庆大霉素之间，以及克林霉素与氨基糖苷类之间。针对产黑素拟杆菌，有效的联合用药是青霉素或克林霉素加庆大霉素以及甲硝唑与螺旋霉素或庆大霉素。偶尔观察到克林霉素和庆大霉素对梭菌属和厌氧球菌有协同作用。协同联合用药在严重厌氧菌感染中具有临床应用潜力。
