Wexler H M, Finegold S M
Medical Service, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073.
Antimicrob Agents Chemother. 1988 Mar;32(3):403-6. doi: 10.1128/AAC.32.3.403.
The activity of two cefoperazone-sulbactam combinations against anaerobic bacteria was tested and compared both with that of cefoperazone alone and with that of other commonly used antimicrobial agents. Imipenem was the most active of the tested agents, followed by chloramphenicol, metronidazole, and cefoperazone-sulbactam (90 to 100% of bacterial growth inhibited). Clindamycin and cefoxitin inhibited approximately 80%, cefoperazone inhibited 63%, and penicillin G inhibited 47% of the strains tested. The agents were variable in activity against the Bacteroides fragilis group, with percents susceptible as follows: cefoperazone-sulbactam, imipenem, metronidazole, and chloramphenicol, 99 to 100%; cefoxitin and clindamycin, approximately 80%; cefoperazone, 49%; and penicillin G, 15.5%.
测试了两种头孢哌酮 - 舒巴坦组合对厌氧菌的活性，并将其与单独使用头孢哌酮的活性以及其他常用抗菌剂的活性进行了比较。亚胺培南是测试药物中活性最强的，其次是氯霉素、甲硝唑和头孢哌酮 - 舒巴坦（抑制90%至100%的细菌生长）。克林霉素和头孢西丁抑制约80%的测试菌株，头孢哌酮抑制63%，青霉素G抑制47%。这些药物对脆弱拟杆菌属菌群的活性各不相同，敏感百分比如下：头孢哌酮 - 舒巴坦、亚胺培南、甲硝唑和氯霉素为99%至100%；头孢西丁和克林霉素约为80%；头孢哌酮为49%；青霉素G为15.5%。
